Department of Psychology, Faculty of Health Sciences, University of Almeria, 04120 Almeria, Spain.
Department of Nursing, Physiotherapy and Medicine, Faculty of Health Sciences, University of Almeria, 04120 Almeria, Spain.
Medicina (Kaunas). 2024 Mar 13;60(3):475. doi: 10.3390/medicina60030475.
: Neurodevelopment is a fragile brain process necessary for learning from the beginning of childhood to adulthood. During the procedure, several risks could affect it, including environmental factors such as neurotoxic chemicals or environmental pollutants and, within them, exposure to pesticides. : This ecological descriptive study attempted to assess the association between environmental exposure to pesticides and neurodevelopmental disorders. This study was conducted on 4830 children diagnosed for 11 years in a total population of 119,897 children in three areas: high, medium, and low greenhouse concentrations. : Chromosomal abnormalities were the most common prenatal disorder (28.6%), while intrauterine physical factors were the least common (0.5%). Among perinatal diagnoses, gestational age less than 32 weeks was the most common (25%), while hyperbilirubinemia requiring exchange transfusion and birth complications was the least common (0.4%). Brain damage was the most common problem detected in postnatal diagnosis (36.7%), while unspecified postnatal abnormalities were the least common (3.1%). : The areas with the highest greenhouse concentration had higher incidences of neurodevelopmental disorders, particularly in boys, and lower age of referral. Chromosomal abnormalities were prevalent for prenatal diagnoses, gestational age below thirty-two weeks for perinatal diagnoses, and brain damage for postnatal diagnoses. Future studies should analyze the connection between pesticide exposure and neurodevelopmental disorders using spatial point pattern analysis.
神经发育是一个脆弱的大脑过程,从儿童期到成年期都需要学习。在这个过程中,有几个风险因素可能会影响它,包括环境因素,如神经毒性化学物质或环境污染物,而在这些因素中,暴露于农药就是其中之一。
这项生态描述性研究试图评估环境暴露于农药与神经发育障碍之间的关联。该研究在三个地区(高、中、低温室浓度区)对 4830 名被诊断为 11 岁的儿童进行了研究,这些儿童的总数为 119897 名。
染色体异常是最常见的产前疾病(28.6%),而宫内物理因素是最不常见的(0.5%)。在围产期诊断中,胎龄小于 32 周的情况最常见(25%),而需要换血的高胆红素血症和分娩并发症的情况最少见(0.4%)。脑损伤是产后诊断中最常见的问题(36.7%),而未指定的产后异常最少见(3.1%)。
温室浓度最高的地区神经发育障碍的发病率更高,特别是男孩,而且转诊年龄更小。染色体异常在产前诊断中较为常见,胎龄小于 32 周在围产期诊断中较为常见,而脑损伤在产后诊断中较为常见。未来的研究应该使用空间点模式分析来分析农药暴露与神经发育障碍之间的联系。