MOE and Shanghai Key Laboratory of Children's Environmental Health, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Neonatology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Environ Int. 2017 Nov;108:119-126. doi: 10.1016/j.envint.2017.08.010. Epub 2017 Aug 24.
Although studies in laboratory animals demonstrate neurodevelopmental deficits caused by prenatal or postnatal organophosphate pesticide (OP) exposure, there is limited evidence on effects induced by not only prenatal but also postnatal exposure of children to OPs.
We measured diethylphosphate (DE), dimethylphosphate (DM), and total dialkylphosphate (DAP) metabolites in maternal and child urine at 12 and 24months of age and examined their relationship with developmental quotients (DQs) in 12-month-old infants and 24-month-old children in Shandong, China.
The median concentrations of total DAP metabolites (DAPs) in child urine [371.97nmol/g creatinine (12-month-old infants), 538.64nmol/g creatinine (24-month-old children)] were higher than those in maternal urine (352.67nmol/g creatinine). Prenatal OP exposure was negatively associated with 24-month-old children's DQs, especially among boys. A 10-fold increase in prenatal DEs and DAPs was associated with a 2.59- and 2.49-point decrease in social domain DQ scores in 24-month-old children (n=262), respectively. However, positive association of postnatal exposure to OPs and 24-month-old children's DQs was observed (n=237). Neither prenatal nor postnatal exposure to OPs was related to 12-month-old infants' DQs.
These data suggested that prenatal OP exposure could adversely affect children's neurodevelopment at 24months of age, especially among boys. The prenatal period might be a critical window of OP exposure. In view of the positive association with postnatal OP exposure, it is necessary to interpret findings with caution.
尽管实验室动物研究表明，产前或产后接触有机磷农药（OP）会导致神经发育缺陷，但仅有有限的证据表明儿童不仅在产前而且在产后接触 OPs 会产生影响。
我们测量了母体和儿童尿液中在 12 个月和 24 个月时的二乙基磷酸酯（DE）、二甲基磷酸酯（DM）和总烷基磷酸酯（DAP）代谢物，并检查了它们与山东 12 个月大婴儿和 24 个月大儿童发育商（DQ）之间的关系。
儿童尿液中总 DAP 代谢物（DAPs）的中位数浓度[12 个月大婴儿（371.97nmol/g 肌酐），24 个月大儿童（538.64nmol/g 肌酐）]高于母体尿液中的浓度（352.67nmol/g 肌酐）。产前 OP 暴露与 24 个月大儿童的 DQ 呈负相关，尤其是男孩。产前 DEs 和 DAPs 增加 10 倍，与 24 个月大儿童社会领域 DQ 评分分别降低 2.59 点和 2.49 点相关（n=262）。然而，观察到儿童期接触 OPs 与 24 个月大儿童的 DQ 呈正相关（n=237）。产前或产后接触 OPs 均与 12 个月大婴儿的 DQ 无关。
这些数据表明，产前 OP 暴露可能会对 24 个月大儿童的神经发育产生不利影响，尤其是男孩。产前时期可能是 OP 暴露的关键时期。鉴于与产后 OP 暴露呈正相关，需要谨慎解释研究结果。
