Australian Research Centre for Population Oral Health (ARCPOH), Adelaide Dental School, University of Adelaide, Adelaide 5005, Australia.
Int J Environ Res Public Health. 2024 Mar 6;21(3):307. doi: 10.3390/ijerph21030307.
Human Papilloma Virus (HPV) infection is a common, preventable, sexually transmitted disease with oncogenic potential and increasing incidence. This study aimed to gain an understanding of the knowledge and awareness of HPV, the HPV vaccine, and HPV-related cancers, and to evaluate the relationship between participant factors and HPV knowledge, vaccination uptake, and high-risk HPV (16/18) infection, among Indigenous Australians. Data from the 12-month follow-up of a longitudinal cohort study were utilized, involving 763 Indigenous Australian adults in South Australia. The data analysis found that the mean 7-item HPV knowledge tool (HPV-KT) score was 2.3 (95% CI: 2.1-2.4), HPV vaccination prevalence was 27.0% (95% CI: 23.6-30.5) and oral HPV 16/18 infection was 4.7% (95% CI: 3.2-6.2). Multivariable log-Poisson regression models showed ratios of approximately 1.5 times higher HPV-KT scores in females, previous recreational drug users, those who had self-rated as having excellent, very good or good general health and who had heard of HPV; and participants who were not HPV vaccinated had 0.8 times (MR = 0.8, 95% CI: 0.7-0.9) lower HPV-KT scores than their counterparts. The findings suggest that culturally safe education strategies are a necessary investment to improve vaccination coverage among Indigenous Australians and to reduce the impact of HPV and related cancers.
人乳头瘤病毒（HPV）感染是一种常见的、可预防的、具有致癌潜能的性传播疾病，且发病率呈上升趋势。本研究旨在了解澳大利亚原住民对 HPV、HPV 疫苗和 HPV 相关癌症的认知和意识，并评估参与者因素与 HPV 知识、疫苗接种率以及高危型 HPV（16/18）感染之间的关系。本研究数据来自于一项纵向队列研究的 12 个月随访，涉及南澳大利亚的 763 名澳大利亚原住民成年人。数据分析发现，7 项 HPV 知识工具（HPV-KT）的平均得分是 2.3（95%CI：2.1-2.4），HPV 疫苗接种率为 27.0%（95%CI：23.6-30.5），口腔 HPV16/18 感染率为 4.7%（95%CI：3.2-6.2）。多变量对数泊松回归模型显示，女性、曾有过消遣性药物使用史、自我评估总体健康状况为优秀、非常好或良好、听说过 HPV 的参与者，其 HPV-KT 得分约高 1.5 倍；而未接种 HPV 疫苗的参与者的 HPV-KT 得分比接种者低 0.8 倍（MR=0.8，95%CI：0.7-0.9）。研究结果表明，文化安全教育策略是必要的投资，可以提高澳大利亚原住民的疫苗接种率，降低 HPV 及相关癌症的影响。
