Kisieliene Inga, Mainelis Antanas, Rudzeviciene Odilija, Bylaite-Bucinskiene Matilda, Wollenberg Andreas
Clinic of Infectious Diseases and Dermatovenereology, Vilnius University, 08411 Vilnius, Lithuania.
Faculty of Mathematics and Informatics, Vilnius University, 03225 Vilnius, Lithuania.
J Clin Med. 2024 Mar 15;13(6):1700. doi: 10.3390/jcm13061700.
Atopic dermatitis (AD) is one of the most common inflammatory skin conditions, thus having a significant impact on the quality of life (QoL) of patients and their families. We performed a survey to gather more data to help describe the burden of AD in Lithuania and to help expand the treatment plan to this important aspect of the disease. A cross-sectional study was conducted involving healthy and AD pediatric patients. The assessment instruments used were the Patient-Oriented Eczema Measure (POEM), QoL, and original questionnaires (the original questionnaire was designed by the authors to determine the demographics, medical history, and treatment methods of the respondents). This study included 302 participants in total: 247 AD patients (51% boys) and 55 non-AD patients (51% boys). The mean age for AD patients was 6.8 ± 4.4. years, and this was 10.5 ± 3.1 years for the control patients. A significant difference was found between the QoL questionnaire scores and the Family Dermatology Life Quality Index (FDLQI) score for the atopic dermatitis group (QoL: 6.3 ± 5.6; FDLQI: 7.1 ± 6.9) and controls (QoL 0.5 ± 1.1; FDLQI 2.1 ± 5.9) ( = 0.000). The mean QoL questionnaire score for severe AD was 14.3 ± 6.2 (very large effect), that for moderate AD was 6.9 ± 4.4 (moderate effect), and that for mild AD was 4.4 ± 4.2 (small effect) ( = 0.000). Our study revealed a moderate effect of AD on dermatology-related QoL in patients and their families. It has been shown that increased disease severity was associated with a greater impairment of QoL in both patients and patient's parents. The burden of AD in children and their parents is considerable and should be taken into account in the management of atopic dermatitis.
特应性皮炎（AD）是最常见的炎症性皮肤病之一，因此对患者及其家人的生活质量（QoL）有重大影响。我们进行了一项调查，以收集更多数据，帮助描述立陶宛AD的负担，并将治疗计划扩展到该疾病的这一重要方面。对健康和患有AD的儿科患者进行了一项横断面研究。使用的评估工具包括患者导向性湿疹量表（POEM）、生活质量量表以及原始问卷（原始问卷由作者设计，用于确定受访者的人口统计学特征、病史和治疗方法）。本研究共纳入302名参与者：247名AD患者（51%为男孩）和55名非AD患者（51%为男孩）。AD患者的平均年龄为6.8±4.4岁，对照患者为10.5±3.1岁。特应性皮炎组（生活质量量表：6.3±5.6；家庭皮肤病生活质量指数（FDLQI）：7.1±6.9）与对照组（生活质量量表0.5±1.1；FDLQI 2.1±5.9）的生活质量问卷得分和FDLQI得分之间存在显著差异（P = 0.000）。重度AD的生活质量问卷平均得分为14.3±6.2（非常大的影响），中度AD为6.9±4.4（中度影响），轻度AD为4.4±4.2（轻度影响）（P = 0.000）。我们的研究揭示了AD对患者及其家人与皮肤病相关生活质量有中度影响。研究表明，疾病严重程度增加与患者及其父母的生活质量受损程度更大有关。儿童及其父母的AD负担相当大，在特应性皮炎的管理中应予以考虑。
