Pediatric Allergy and Immunology Clinic, Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey;
Pediatric Allergy and Immunology Clinic, Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey.
Allergol Immunopathol (Madr). 2022 May 1;50(3):55-61. doi: 10.15586/aei.v50i3.556. eCollection 2022.
Atopic dermatitis (AD) is a chronic, relapsing, inflammatory skin disease. In this study, the relationship between the severity of AD and the quality of life (QoL) of patients and their families were evaluated; also, the factors that predict the severity of AD and the QoL index were determined.
Infants with AD were enrolled in the study. Pruritus, sleep disturbance, and dermatitis severity scores were obtained. The QoL of infants was assessed using the Infants' Dermatitis Quality of Life Index (IDQOL), while the Family Dermatology Life Quality Index (FDLQI) was used to assess the impact of disease on the QoL of parents.
122 patients diagnosed with AD were enrolled in the study. The correlation analysis of score showed a positive correlation between IDQOL and FDLQI (r = 0.444, p < 0.0001). Positive correlations between the pruritus, sleep disturbance, Severity Scoring of Atopic Dermatitis (SCORAD), Eczema Area and Severity Index (EASI), and dermatitis severity scores and the QoL indexes were found. While pruritus, sleep disturbance scores, and EASI were the most significant parameters for predicting a severe SCORAD score, IDOQL, FDLQI, and SCORAD were the most significant parameters for predicting severe EASI. In the analysis of QoL indexes, sleep disturbance and FDLQI were the most significant parameters for predicting severe IDQOL index, while IDQOL was the most significant parameter for predicting severe FDLQI scores.
AD has a negative effect on the QoL of infants and their parents. Pruritus and sleep disturbance should be evaluated during clinical practice due to their strong relationship with disease severity and QoL index.
特应性皮炎（AD）是一种慢性、复发性、炎症性皮肤病。本研究评估了 AD 严重程度与患者及其家属生活质量（QoL）的关系，并确定了预测 AD 严重程度和 QoL 指数的因素。
纳入 AD 患儿。记录瘙痒、睡眠障碍和皮炎严重程度评分。采用婴儿特应性皮炎生活质量指数（IDQOL）评估婴儿 QoL，采用家庭皮肤病生活质量指数（FDLQI）评估疾病对父母 QoL 的影响。
共纳入 122 例 AD 患儿。评分的相关分析显示，IDQOL 与 FDLQI 呈正相关（r=0.444，p<0.0001）。瘙痒、睡眠障碍、特应性皮炎严重程度评分（SCORAD）、湿疹面积和严重程度指数（EASI）和皮炎严重程度评分与 QoL 指数呈正相关。瘙痒、睡眠障碍评分和 EASI 是预测严重 SCORAD 评分的最重要参数，而 IDOQL、FDLQI 和 SCORAD 是预测严重 EASI 的最重要参数。在 QoL 指数分析中，睡眠障碍和 FDLQI 是预测严重 IDQOL 指数的最重要参数，而 IDQOL 是预测严重 FDLQI 评分的最重要参数。
AD 对婴儿及其父母的 QoL 有负面影响。在临床实践中，应评估瘙痒和睡眠障碍，因为它们与疾病严重程度和 QoL 指数密切相关。
