转录因子 MYB 作为治疗靶点：最新进展。
Transcription Factor MYB as Therapeutic Target: Current Developments.
机构信息
Institute for Biochemistry, University of Münster, 48149 Münster, Germany.
出版信息
Int J Mol Sci. 2024 Mar 12;25(6):3231. doi: 10.3390/ijms25063231.
Abstract
The MYB protein is a pivotal player in the cellular transcriptional network, influencing major important processes such as cell proliferation, differentiation, and apoptosis. Because of its role in oncogenesis, MYB is now a compelling target for therapeutic interventions in cancer research. This review summarizes its molecular functions and current therapeutic approaches aiming to inhibit its oncogenic activity.
摘要
MYB 蛋白是细胞转录网络中的关键参与者，影响细胞增殖、分化和凋亡等重要过程。由于其在肿瘤发生中的作用，MYB 现在成为癌症研究中治疗干预的一个有吸引力的靶点。本文总结了其分子功能和目前旨在抑制其致癌活性的治疗方法。
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