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揭示 GPR18 信号通路的作用：RvD2 和其他配体如何调节和缓解各种健康障碍中的炎症

Uncovering the Power of GPR18 Signalling: How RvD2 and Other Ligands Could Have the Potential to Modulate and Resolve Inflammation in Various Health Disorders.

机构信息

Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St., 30-688 Krakow, Poland.

出版信息

Molecules. 2024 Mar 12;29(6):1258. doi: 10.3390/molecules29061258.

DOI:10.3390/molecules29061258
PMID:38542895
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10976181/
Abstract

The resolution of inflammation is the primary domain of specialised pro-resolving mediators (SPMs), which include resolvins, protectins, and their forms synthesised under the influence of aspirin and the maresins. The role of these SPMs has been discussed by many authors in the literature, with particular reference to neuroinflammation and significant neurological disorders. This review discusses the role of G protein-coupled receptor 18 (GPR18), resolvin D2 (RvD2) activity, and the GPR18-RvD2 signalling axis, as well as the role of small molecule ligands of GPR18 in inflammation in various health disorders (brain injuries, neuropathic pain, neurodegenerative/cardiometabolic/cardiovascular/gastrointestinal diseases, peritonitis, periodontitis, asthma and lung inflammation, Duchenne muscular dystrophy, SARS-CoV-2-induced inflammation, and placenta disorders. The idea of biological intervention through modulating GPR18 signalling is attracting growing attention because of its great therapeutic potential. With this paper, we aimed to present a comprehensive review of the most recent literature, perform a constructive view of data, and point out research gaps.

摘要

炎症的消退是专门的促解决介质（SPM）的主要作用领域，其中包括 resolvins、protectins 及其在阿司匹林和maresin 影响下合成的形式。许多作者在文献中讨论了这些 SPM 的作用，特别是在神经炎症和重大神经疾病方面。本综述讨论了 G 蛋白偶联受体 18（GPR18）、resolvin D2（RvD2）活性和 GPR18-RvD2 信号轴的作用，以及 GPR18 的小分子配体在各种健康障碍（脑损伤、神经病理性疼痛、神经退行性/心脏代谢/心血管/胃肠道疾病、腹膜炎、牙周炎、哮喘和肺部炎症、杜氏肌营养不良症、SARS-CoV-2 诱导的炎症和胎盘障碍）中的炎症中的作用。通过调节 GPR18 信号来进行生物干预的想法因其巨大的治疗潜力而引起了越来越多的关注。通过本文，我们旨在对最新文献进行全面综述，对数据进行建设性的观察，并指出研究空白。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68c/10976181/5e6f7212a7ee/molecules-29-01258-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68c/10976181/e5eeb5037cce/molecules-29-01258-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68c/10976181/8451f04a5ee9/molecules-29-01258-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68c/10976181/e014a02c4b90/molecules-29-01258-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68c/10976181/6fe0c5d76646/molecules-29-01258-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68c/10976181/c09664e05c29/molecules-29-01258-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68c/10976181/ab06ce33fc53/molecules-29-01258-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68c/10976181/5e6f7212a7ee/molecules-29-01258-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68c/10976181/e5eeb5037cce/molecules-29-01258-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68c/10976181/8451f04a5ee9/molecules-29-01258-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68c/10976181/e014a02c4b90/molecules-29-01258-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68c/10976181/6fe0c5d76646/molecules-29-01258-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68c/10976181/c09664e05c29/molecules-29-01258-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68c/10976181/ab06ce33fc53/molecules-29-01258-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68c/10976181/5e6f7212a7ee/molecules-29-01258-g007.jpg

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[1]
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[6]
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[7]
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[8]
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[9]
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[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
Emerging Implications of Serum Resolvin D2 as a Biochemical Marker for Severity Assessment and Prognosis Prediction Following Moderate-Severe Traumatic Brain Injury: A Prospective Cohort Study.

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[9]
The Involvement of Resolvins in Pathological Mechanisms of Periodontal Disease Associated with Type 2 Diabetes: A Narrative Review.

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[10]
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本文引用的文献

[1]
Resolvin D2 regulates type 2 inflammatory responses and promotes resolution of mouse allergic inflammation.

Allergy. 2024-3

[2]
Resolvin D2 activates anti-inflammatory microglia via restoring autophagy flux and alleviate neuropathic pain following spinal cord injury in rats.

Exp Neurol. 2023-12

[3]
Gpr18 agonist dampens inflammation, enhances myogenesis, and restores muscle function in models of Duchenne muscular dystrophy.

Front Cell Dev Biol. 2023-8-14

[4]
Lung Inflammation Resolution by RvD1 and RvD2 in a Receptor-Dependent Manner.

Pharmaceutics. 2023-5-18

[5]
Novel GPR18 Ligands in Rodent Pharmacological Tests: Effects on Mood, Pain, and Eating Disorders.

Int J Mol Sci. 2023-5-20

[6]
Insights into the role of the resolvin D2-GPR18 signaling axis in cardiovascular physiology and disease.

Adv Pharmacol. 2023

[7]
NF-κB in monocytes and macrophages - an inflammatory master regulator in multitalented immune cells.

Front Immunol. 2023

[8]
Resolvin D2 Reduces Chronic Neuropathic Pain and Bone Cancer Pain via Spinal Inhibition of IL-17 Secretion, CXCL1 Release and Astrocyte Activation in Mice.

Brain Sci. 2023-1-15

[9]
Resolvin D2 induces anti-microbial mechanisms in a model of infectious peritonitis and secondary lung infection.

Front Immunol. 2022

[10]
Placental Inflammation Leads to Abnormal Embryonic Heart Development.

Circulation. 2023-3-21

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