Ghemiș Larisa, Goriuc Ancuta, Jipu Raluca, Foia Liliana Georgeta, Luchian Ionut
Department of General and Oral Biochemistry, Faculty of Dental Medicine, "Grigore T. Popa" University of Medicine and Pharmacy Iaşi, 700115 Iași, Romania.
Department of Morpho-Functional Sciences, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy Iași, 700115 Iași, Romania.
Int J Mol Sci. 2024 Nov 28;25(23):12784. doi: 10.3390/ijms252312784.
Resolvins are specialized pro-resolving mediators (SPMs) derived from omega-3 fatty acids that play a critical role in resolving inflammation and restoring tissues to a state of health after an immune response. Their role in chronic inflammatory conditions highlights their importance in maintaining a balance between an effective immune response and the resolution of inflammation to prevent tissue damage. Periodontal disease is a chronic inflammatory condition affecting the tissues surrounding the teeth, leading to gum damage and bone loss. Chronic inflammation in periodontal disease can exacerbate systemic inflammation and influence other conditions, such as diabetes. There is a bidirectional relationship between diabetes and periodontal disease, as both are characterized by chronic inflammation and exacerbate systemic and oral health complications. This narrative review aims to synthesize the current knowledge on how resolvins influence inflammatory pathways and the tissue repair mechanism in periodontal disease in patients with type 2 diabetes. Furthermore, this review serves as a foundation for developing targeted therapeutic strategies, addressing the pressing need for effective treatments that consider both systemic and oral health outcomes.
消退素是一类源自ω-3脂肪酸的特殊促消退介质（SPM），在炎症消退以及免疫反应后将组织恢复至健康状态的过程中发挥关键作用。它们在慢性炎症性疾病中的作用凸显了其在维持有效免疫反应与炎症消退之间平衡以防止组织损伤方面的重要性。牙周病是一种影响牙齿周围组织的慢性炎症性疾病，会导致牙龈损伤和骨质流失。牙周病中的慢性炎症会加剧全身炎症，并影响其他病症，如糖尿病。糖尿病与牙周病之间存在双向关系，因为二者均以慢性炎症为特征，且会加剧全身和口腔健康并发症。本叙述性综述旨在综合当前关于消退素如何影响2型糖尿病患者牙周病炎症途径和组织修复机制的知识。此外，本综述为制定针对性治疗策略奠定基础，满足了对兼顾全身和口腔健康结果的有效治疗的迫切需求。
