Hamad Islam, Harb Amani A, Bustanji Yasser
Department of Pharmacy, Faculty of Health Sciences, American University of Madaba, Amman 11821, Jordan.
Department of Basic Sciences, Faculty of Arts and Sciences, Al-Ahliyya Amman University, Amman 19111, Jordan.
Pharmaceutics. 2024 Mar 14;16(3):400. doi: 10.3390/pharmaceutics16030400.
Lipid-bilayer-based liposomes are gaining attention in scientific research for their versatile role in drug delivery. With their amphiphilic design, liposomes efficiently encapsulate and deliver drugs to targeted sites, offering controlled release. These artificial structures hold great promise in advancing cancer therapy methodologies. Bibliometric research analyzes systematic literary data statistically. This study used bibliometric indicators to examine, map, and evaluate the applications of liposomes in cancer therapy. A Scopus search was conducted to identify all English-language peer-reviewed scientific publications on the applications of liposomes in cancer therapy within the past twenty years. Bibliometric indicators were calculated using VOSviewer and Biblioshiny. We produced thematic, conceptual, and visualization charts. A total of 14,873 published documents were obtained. The procedure of keyword mapping has effectively identified the main areas of research concentration and prevailing trends within this specific field of study. The significant clusters discovered through theme and hotspot analyses encompassed many topics such as the use of multiple strategies in chemotherapy and different forms of cancer, the study of pharmacokinetics and nanomedicine, as well as the investigation of targeted drug delivery, cytotoxicity, and gene delivery. Liposomes were employed as drug delivery systems so as to selectively target cancer cells and improve the bioavailability of anticancer drugs. The work showcased the capacity to tailor these liposomes for accurate drug delivery by including potent anticancer medications. Our findings not only bring attention to the latest progress in utilizing liposomes for cancer treatment but also underscore the vital need for ongoing research, collaborative efforts, and the effective translation of these breakthroughs into tangible clinical applications, emphasizing the dynamic and evolving nature of cancer therapeutics.
基于脂质双层的脂质体因其在药物递送中的多功能作用而在科学研究中受到关注。凭借其两亲性设计，脂质体能够有效地包裹药物并将其递送至靶向部位，实现控释。这些人工结构在推进癌症治疗方法方面具有巨大潜力。文献计量研究对系统的文献数据进行统计分析。本研究使用文献计量指标来审视、绘制图谱并评估脂质体在癌症治疗中的应用。通过Scopus搜索，识别出过去二十年内所有关于脂质体在癌症治疗中应用的英文同行评审科学出版物。使用VOSviewer和Biblioshiny计算文献计量指标。我们制作了主题、概念和可视化图表。共获得14,873篇已发表文献。关键词映射过程有效地确定了这一特定研究领域内的主要研究集中领域和主要趋势。通过主题和热点分析发现的重要聚类涵盖了许多主题，如化疗中多种策略的使用和不同类型的癌症、药代动力学和纳米医学的研究，以及靶向药物递送、细胞毒性和基因递送的研究。脂质体被用作药物递送系统，以便选择性地靶向癌细胞并提高抗癌药物的生物利用度。这项工作展示了通过纳入强效抗癌药物来定制这些脂质体以实现精确药物递送的能力。我们的研究结果不仅关注脂质体用于癌症治疗的最新进展，还强调了持续研究、合作努力以及将这些突破有效转化为切实临床应用的迫切需求，突出了癌症治疗的动态性和不断发展的性质。
