The microbiota in the oral cavity has a strict connection to its host. Its imbalance may determine oral diseases and can also have an impact on the systemic health. Probiotic strains may help in the restoration of a balanced condition. For this purpose, we screened the antibacterial and antiadhesive activities of many viable probiotic strains ( PBS066, LCR030, LG050, PBS067, PBS072, LRH020, subsp. BL050, LPC 1101, LPC 1082, and LPC 1114) against two main oral pathogens, and , involved in dental caries and periodontal disease development and progression. Considering both the agar overlay preventive and treatment models, seven probiotics determined greater inhibition zones against the tested pathogens. This behavior was further analyzed by the plate count method and scanning electron microscope imaging. PBS067, LRH020, LPC 1101, LPC 1082, and LPC 1114 prevent the growth and adhesion of oral pathogens in a strain-specific manner ( < 0.0001). These probiotics might be considered as an alternative effective adjuvant to improve oral and systemic well-being for future personalized treatments.