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探索特定益生菌菌株对口腔病原菌的体外抗菌潜力。

Exploring the In Vitro Antibacterial Potential of Specific Probiotic Strains against Oral Pathogens.

作者信息

Squarzanti Diletta F, Dell'Atti Federica, Scalia Alessandro C, Najmi Ziba, Cochis Andrea, Malfa Patrizia

机构信息

Synbalance Srl, 21040 Origgio, VA, Italy.

Immunomics Laboratory, Department of Health Sciences, Center for Translational Research on Autoimmune and Allergic Diseases (CAAD), University of Eastern Piedmont, 28100 Novara, NO, Italy.

出版信息

Microorganisms. 2024 Feb 21;12(3):441. doi: 10.3390/microorganisms12030441.

Abstract

The microbiota in the oral cavity has a strict connection to its host. Its imbalance may determine oral diseases and can also have an impact on the systemic health. Probiotic strains may help in the restoration of a balanced condition. For this purpose, we screened the antibacterial and antiadhesive activities of many viable probiotic strains ( PBS066, LCR030, LG050, PBS067, PBS072, LRH020, subsp. BL050, LPC 1101, LPC 1082, and LPC 1114) against two main oral pathogens, and , involved in dental caries and periodontal disease development and progression. Considering both the agar overlay preventive and treatment models, seven probiotics determined greater inhibition zones against the tested pathogens. This behavior was further analyzed by the plate count method and scanning electron microscope imaging. PBS067, LRH020, LPC 1101, LPC 1082, and LPC 1114 prevent the growth and adhesion of oral pathogens in a strain-specific manner ( < 0.0001). These probiotics might be considered as an alternative effective adjuvant to improve oral and systemic well-being for future personalized treatments.

摘要

口腔微生物群与其宿主有着紧密的联系。其失衡可能会引发口腔疾病,还可能对全身健康产生影响。益生菌菌株或许有助于恢复平衡状态。为此,我们筛选了多种活性益生菌菌株(PBS066、LCR030、LG050、PBS067、PBS072、LRH020、亚种BL050、LPC 1101、LPC 1082和LPC 1114)对两种主要口腔病原体的抗菌和抗黏附活性,这两种病原体与龋齿和牙周疾病的发生及发展有关。考虑到琼脂覆盖预防和治疗模型,七种益生菌对受试病原体产生了更大的抑菌圈。通过平板计数法和扫描电子显微镜成像对这种现象进行了进一步分析。PBS067、LRH020、LPC 1101、LPC 1082和LPC 1114以菌株特异性方式抑制口腔病原体的生长和黏附(P<0.0001)。这些益生菌可能被视为一种有效的替代佐剂,用于未来个性化治疗以改善口腔和全身健康。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7b3/10972368/3de6e0b6b4b0/microorganisms-12-00441-g001.jpg

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