Shahin Reem K, Elkady Mohamed A, Abulsoud Ahmed I, Abdelmaksoud Nourhan M, Abdel Mageed Sherif S, El-Dakroury Walaa A, Zewail Moataz B, Elazazy Mahmoud, Sobhy Mohamed H, Nomier Yousra, Elazazy Ola, Elballal Mohammed S, Mohammed Osama A, Midan Heba M, Elrebehy Mahmoud A, Ziada Bassant O, Doghish Ahmed S
Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt.
Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt.
Pathol Res Pract. 2023 Aug;248:154684. doi: 10.1016/j.prp.2023.154684. Epub 2023 Jul 13.
Gallbladder cancer (GBC) is characterized by a highly invasive nature and a poor prognosis, with adenocarcinoma being the main histological subtype. According to statistical data, patients diagnosed with advanced GBC have a survival rate of less than 5% for 5 years. Despite the novel therapeutic techniques, the unsatisfactory results could be related to the underlying biology of tumor cells and resistance to chemotherapy. Early diagnosis is more important than clinical therapy as it assists in determining the pathological stage of cancer and facilitates the selection of appropriate medication. Hence, it is very important to understand the precise pathogenesis of GBC and to discover potential novel biomarkers for early diagnosis of GBC. Non-coding RNAs, such as microRNAs, long non-coding RNAs, and circular RNAs, have been found to influence the transcriptional regulation of target genes associated with cancer, either directly or indirectly. microRNAs are a group of small, non-coding, single-stranded RNAs that are expressed endogenously. miRNAs play significant roles in various fundamental cellular processes. Therefore, miRNAs have the potential to serve as valuable biomarkers and therapeutic targets for GBC.
胆囊癌（GBC）具有高度侵袭性且预后较差，腺癌是主要的组织学亚型。据统计数据，被诊断为晚期胆囊癌的患者5年生存率低于5%。尽管有新的治疗技术，但结果不尽人意可能与肿瘤细胞的潜在生物学特性以及对化疗的耐药性有关。早期诊断比临床治疗更重要，因为它有助于确定癌症的病理分期并便于选择合适的药物。因此，了解胆囊癌的确切发病机制并发现早期诊断胆囊癌的潜在新型生物标志物非常重要。非编码RNA，如微小RNA、长链非编码RNA和环状RNA，已被发现可直接或间接影响与癌症相关的靶基因的转录调控。微小RNA是一组内源性表达的小的、非编码的单链RNA。微小RNA在各种基本细胞过程中发挥重要作用。因此，微小RNA有潜力成为胆囊癌有价值的生物标志物和治疗靶点。
