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聚焦超声消融手术治疗腹壁子宫内膜异位症的临床价值

[Clinical value of focused ultrasound ablation surgery in the treatment of abdominal wall endometriosis].

作者信息

Ding K, Kang Y J, Zhao L, Sang C M, Cheng H Y, Zhao S P

机构信息

Department of Gynecology, Qingdao Women and Children's Hospital, Qingdao 266011, China.

出版信息

Zhonghua Fu Chan Ke Za Zhi. 2024 Mar 25;59(3):192-199. doi: 10.3760/cma.j.cn112141-20231018-00157.

Abstract

To explore the effectiveness and safety of focused ultrasound ablation surgery (FUAS) for abdominal wall endometriosis. From November 2019 to October 2022, a total of 34 patients with abdominal wall endometriosis who underwent FUAS were collected, and their clinical features, imaging features, intraoperative treatment and side effects after treatment were analyzed retrospectively, and the improvement of symptoms and re-intervention were followed up. (1) Characteristics of clinical data: the average age of 34 patients with abdominal wall endometriosis was (32.8±3.8) years old. The largest diameter of the lesion was 48 mm, and the median lesion diameter was 24 mm. Thirty cases (88%, 30/34) had moderate to severe periodic pain in abdominal incision before FUAS. All patients were diagnosed by preoperative magnetic resonance imaging, including 19 cases (56%, 19/34) of superficial type, 8 cases (24%, 8/34) of intermediate type and 7 cases (21%, 7/34) of deep type. (2) FUAS treatment parameters: ablation was completed with average operation time of (64±18) minutes, average sonication time was (385±108) s, (103±11) W of average power, (38 819±16 309) J of average total energy, the average treatment area volume of (3.11±1.42) cm, and (377.79±106.34) s/h of average treatment intensity. (3) Efficiency: the pain of patients after FUAS was significantly relieved, and the pain scores of patients after 1 month, 3 months, 6 months and 1 year after FUAS were significantly decreased (=-4.66, -5.13, -5.11 and -4.91, all 0.01). One year after FUAS, the near relief and effective pain relief rate was 74% (25/34), and the clinical effective rate was 85% (29/34). Five patients recurred after one year, including 3 patients who underwent abdominal wall endometriosis lesion resection and 2 patients who received drug treatment. One month after FUAS, the size of the lesion did not change significantly compared with that before FUAS (>0.05), and the size of the lesion decreased significantly after FUAS at 3 months, 6 months and 1 year (=-2.15, -2.67 and -3.41, all <0.05). It has no difference in pain relief among different types (>0.05), but has significant difference in focus reduction among three types (<0.01). (4) Safety: there were 34 cases (100%, 34/34) of skin burning sensation, 19 cases (56%, 19/34) of pain in the treatment area and 2 cases (6%, 2/34) of hematuria. All patients got better after corresponding treatments. FUAS is safe and effective for the treatment of abdominal wall endometriosis, which has clinical application value.

摘要

探讨聚焦超声消融手术(FUAS)治疗腹壁子宫内膜异位症的有效性和安全性。收集2019年11月至2022年10月期间共34例行FUAS治疗的腹壁子宫内膜异位症患者,回顾性分析其临床特征、影像学特征、术中治疗及治疗后副作用,并随访症状改善情况及再次干预情况。(1)临床资料特点:34例腹壁子宫内膜异位症患者平均年龄为(32.8±3.8)岁。病灶最大直径为48mm,病灶中位直径为24mm。30例(88%,30/34)患者在FUAS术前腹部切口有中度至重度周期性疼痛。所有患者均经术前磁共振成像诊断,其中浅表型19例(56%,19/34),中间型8例(24%,8/34),深部型7例(21%,7/34)。(2)FUAS治疗参数:消融完成时平均手术时间为(64±18)分钟,平均超声照射时间为(385±108)秒,平均功率为(103±11)瓦,平均总能量为(38 819±16 309)焦,平均治疗区域体积为(3.11±1.42)立方厘米,平均治疗强度为(377.79±106.34)秒/小时。(3)疗效:FUAS术后患者疼痛明显缓解,FUAS术后1个月、3个月、6个月及1年患者疼痛评分均显著降低(=-4.66、-5.13、-5.11及-4.91,均P<0.01)。FUAS术后1年,疼痛近缓解及有效缓解率为74%(25/34),临床有效率为85%(29/34)。1年后5例复发,其中3例行腹壁子宫内膜异位症病灶切除术,2例接受药物治疗。FUAS术后1个月,病灶大小与术前相比无明显变化(P>0.05),FUAS术后3个月、6个月及1年病灶大小显著减小(=-2.15、-2.67及-3.41,均P<0.05)。不同类型间疼痛缓解无差异(P>0.05),但三种类型间病灶缩小有显著差异(P<0.01)。(4)安全性:皮肤有烧灼感34例(100%,34/34),治疗区域疼痛19例(56%,19/34),血尿2例(6%,2/34)。经相应治疗后所有患者均好转。FUAS治疗腹壁子宫内膜异位症安全有效,具有临床应用价值。

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