School of Public Health, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.
Department of Surveillance and Research, National Center for Communicable Diseases, Ulaanbaatar, Mongolia.
Influenza Other Respir Viruses. 2024 Apr;18(4):e13277. doi: 10.1111/irv.13277.
Following the first locally transmitted case in Sukhbaatar soum, Selenge Province, we aimed to investigate the ultimate scale of the epidemic in the scenario of uninterrupted transmission.
This was a prospective case study following the locally modified WHO FFX cases generic protocol. A rapid response team collected data from November 14 to 29, 2020. We created a stochastic process to draw many transmission chains from this greater distribution to better understand and make inferences regarding the outbreak under investigation.
The majority of the cases involved household transmissions (35, 52.2%), work transmissions (20, 29.9%), index (5, 7.5%), same apartment transmissions (2, 3.0%), school transmissions (2, 3.0%), and random contacts between individuals transmissions (1, 1.5%). The posterior means of the basic reproduction number of both the asymptomatic cases and the presymptomatic cases (1.35 [95% CrI 0.88-1.86] and 1.29 [95% CrI 0.67-2.10], respectively) were lower than that of the symptomatic cases (2.00 [95% Crl 1.38-2.76]).
Our study highlights the heterogeneity of COVID-19 transmission across different symptom statuses and underscores the importance of early identification and isolation of symptomatic cases in disease control. Our approach, which combines detailed contact tracing data with advanced statistical methods, can be applied to other infectious diseases, facilitating a more nuanced understanding of disease transmission dynamics.
在色楞格省苏赫巴托县首次发生本地传播病例后,我们旨在调查在连续传播情况下疫情的最终规模。
这是一项采用当地修改后的世界卫生组织 FFX 通用病例方案的前瞻性病例研究。一个快速反应小组于 2020 年 11 月 14 日至 29 日收集数据。我们创建了一个随机过程,从更大的分布中抽取许多传播链,以便更好地理解和推断正在调查的疫情。
大多数病例涉及家庭传播(35 例,52.2%)、工作传播(20 例,29.9%)、指数病例(5 例,7.5%)、同一公寓传播(2 例,3.0%)、学校传播(2 例,3.0%)和个体之间随机接触传播(1 例,1.5%)。无症状病例和有症状前病例的基本繁殖数的后验平均值(分别为 1.35[95%置信区间 0.88-1.86]和 1.29[95%置信区间 0.67-2.10])均低于有症状病例(2.00[95%置信区间 1.38-2.76])。
我们的研究强调了 COVID-19 在不同症状状态下传播的异质性,并强调了早期识别和隔离有症状病例在疾病控制中的重要性。我们的方法结合了详细的接触追踪数据和先进的统计方法,可以应用于其他传染病,有助于更细致地了解疾病传播动态。