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卵巢弥漫性大B细胞淋巴瘤伴副肿瘤性硬化性皮肤病变

Diffuse Large B-cell Lymphoma of the Ovaries Presenting With a Paraneoplastic Sclerotic Skin Lesion.

作者信息

Garza Nicholas J, Arulmozhi Kavitha, LePhong Christopher, Titapiwatanakun Ruetima, Fernandez Karen S

机构信息

Pediatrics, Valley Children's Healthcare, Madera, USA.

Pathology and Laboratory Medicine, Valley Children's Healthcare, Madera, USA.

出版信息

Cureus. 2024 Feb 26;16(2):e54974. doi: 10.7759/cureus.54974. eCollection 2024 Feb.

DOI:10.7759/cureus.54974
PMID:38544648
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10972626/
Abstract

Paraneoplastic presentations are often the initial presenting symptom of a malignant process. A 15-year-old female presented with a progressively growing, sclerotic lesion of the neck restricting the range of motion. She was found to have bilateral ovarian tumors that proved to be diffuse large B-cell lymphoma (DLBCL). After starting cyclophosphamide, vincristine, and prednisone (COP), she had a rapid and complete resolution of the sclerotic lesion, as well as a favorable response to the neoplastic process. In this report, we present a very rare case of extranodal lymphoma associated with a paraneoplastic skin lesion.

摘要

副肿瘤表现通常是恶性疾病的首发症状。一名15岁女性因颈部出现逐渐增大的硬化性病变，限制了活动范围而就诊。她被发现患有双侧卵巢肿瘤，病理证实为弥漫性大B细胞淋巴瘤（DLBCL）。在开始使用环磷酰胺、长春新碱和泼尼松（COP）治疗后，她颈部的硬化性病变迅速完全消退，并且对肿瘤性疾病也有良好反应。在本报告中，我们呈现了一例非常罕见的结外淋巴瘤伴副肿瘤性皮肤病变的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d482/10972626/8fc22d107fe3/cureus-0016-00000054974-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d482/10972626/e54b7b2bd0a0/cureus-0016-00000054974-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d482/10972626/8fc22d107fe3/cureus-0016-00000054974-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d482/10972626/e54b7b2bd0a0/cureus-0016-00000054974-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d482/10972626/8fc22d107fe3/cureus-0016-00000054974-i02.jpg

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本文引用的文献

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Ovarian Non-Hodgkin Lymphoma Revealed by Bone Metastasis: A Rare Pediatric Case.以骨转移为表现的卵巢非霍奇金淋巴瘤：1例罕见儿科病例
Case Rep Pediatr. 2021 Apr 20;2021:8826688. doi: 10.1155/2021/8826688. eCollection 2021.
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Ovarian cancer in adolescents and young adults.青少年和年轻女性的卵巢癌。
Pediatr Blood Cancer. 2019 Mar;66(3):e27512. doi: 10.1002/pbc.27512. Epub 2018 Oct 23.
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Primary bilateral ovarian Burkitt lymphoma; a rare issue in gynecologic oncology.原发性双侧卵巢伯基特淋巴瘤；妇科肿瘤学中的罕见病例。
J Surg Case Rep. 2018 May 18;2018(5):rjy113. doi: 10.1093/jscr/rjy113. eCollection 2018 May.
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Characteristics and outcome of pediatric non-Hodgkin lymphoma patients with ovarian infiltration at presentation.初诊时伴有卵巢浸润的小儿非霍奇金淋巴瘤患者的特征和结局。
Pediatr Blood Cancer. 2013 Dec;60(12):2054-9. doi: 10.1002/pbc.24582. Epub 2013 Jul 19.
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Scleromyxedema: a multicenter study of characteristics, comorbidities, course, and therapy in 30 patients.硬肿性黏液水肿：30 例患者的特征、合并症、病程和治疗的多中心研究。
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Evaluation of BCL-6, CD10, CD138 and MUM-1 expression in diffuse large B-cell lymphoma patients: CD138 is a marker of poor prognosis.弥漫性大B细胞淋巴瘤患者中BCL-6、CD10、CD138和MUM-1表达的评估：CD138是预后不良的标志物。
Asian Pac J Cancer Prev. 2012;13(7):3037-46. doi: 10.7314/apjcp.2012.13.7.3037.
7
The impact of age and gender on biology, clinical features and treatment outcome of non-Hodgkin lymphoma in childhood and adolescence.年龄和性别对儿童及青少年非霍奇金淋巴瘤生物学特性、临床特征及治疗结果的影响。
Br J Haematol. 2005 Oct;131(1):39-49. doi: 10.1111/j.1365-2141.2005.05735.x.
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Paraneoplastic manifestations of lymphoma.淋巴瘤的副肿瘤表现
Clin Lymphoma. 2004 Jun;5(1):29-36. doi: 10.3816/clm.2004.n.007.
9
B large-cell lymphoma in children and adolescents.儿童和青少年的B大细胞淋巴瘤。
Cancer Treat Rev. 2003 Apr;29(2):91-8. doi: 10.1016/s0305-7372(02)00108-1.
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