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根治性肾切除术后29年出现的孤立性胰腺转移肾透明细胞癌

Isolated Pancreatic Metastasis From Renal Clear Cell Renal Cell Carcinoma 29 Years After Radical Nephrectomy.

作者信息

Fujiwara Sho, Koyamada Nozomi, Nishimura Ryuichi, Miyazawa Koji, Miyazaki Shukichi

机构信息

Department of Surgery, Iwate Prefectural Chubu Hospital, Kitakami, JPN.

出版信息

Cureus. 2024 Feb 26;16(2):e54973. doi: 10.7759/cureus.54973. eCollection 2024 Feb.

DOI:10.7759/cureus.54973
PMID:38544660
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10972610/
Abstract

Isolated metastatic tumors of the pancreas from other origins are only 2-3% of pancreatic cancers, and renal cell carcinoma is the most common origin of metastasis. It is challenging to differentiate between pancreatic tumors and those with a history of renal cancer to optimize treatment and management of this tumor. Here, we present a case of isolated renal cell cancer metastasis to the pancreas, which occurred 29 years after the radical nephrectomy. Surgical resection and pancreatectomy is a feasible treatment because of the low rate of complication and favorable prognosis. However, isolated metastatic pancreatic cancer from renal cell cancer is rare and has relatively high risk of recurrence. Therefore, a larger sample size is necessary to evaluate long-term oncologic outcomes and to optimize diagnostic and therapeutic strategies.

摘要

来自其他原发部位的孤立性胰腺转移瘤仅占胰腺癌的2%-3%,肾细胞癌是最常见的转移原发部位。鉴别胰腺肿瘤与有肾癌病史的肿瘤,以优化该肿瘤的治疗和管理具有挑战性。在此,我们报告一例孤立性肾细胞癌转移至胰腺的病例,该病例发生在根治性肾切除术后29年。手术切除及胰腺切除术是一种可行的治疗方法,因为并发症发生率低且预后良好。然而,肾细胞癌孤立性转移至胰腺较为罕见,且复发风险相对较高。因此,需要更大的样本量来评估长期肿瘤学结局并优化诊断和治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c735/10972610/6b2b955b5756/cureus-0016-00000054973-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c735/10972610/827fc13f0ffc/cureus-0016-00000054973-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c735/10972610/6b2b955b5756/cureus-0016-00000054973-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c735/10972610/827fc13f0ffc/cureus-0016-00000054973-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c735/10972610/6b2b955b5756/cureus-0016-00000054973-i02.jpg

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本文引用的文献

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Metastatic renal cell carcinoma to the pancreas and other sites-a multicenter retrospective study.胰腺及其他部位转移性肾细胞癌——一项多中心回顾性研究
EClinicalMedicine. 2023 Jun 1;60:102018. doi: 10.1016/j.eclinm.2023.102018. eCollection 2023 Jun.
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Long-term Outcomes After Surgical Resection of Pancreatic Metastases from Renal Clear-Cell Carcinoma.肾透明细胞癌胰腺转移灶手术切除后的长期预后
Ann Surg Oncol. 2021 Jun;28(6):3100-3108. doi: 10.1245/s10434-021-09649-w. Epub 2021 Feb 11.
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胰腺转移性肾细胞癌:临床特征与治疗结果
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BMC Cancer. 2015 Feb 12;15:46. doi: 10.1186/s12885-015-1050-2.
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Surgical resection does not improve survival in patients with renal metastases to the pancreas in the era of tyrosine kinase inhibitors.在酪氨酸激酶抑制剂时代,手术切除并不能提高胰腺肾转移患者的生存率。
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