美国成年人血浆多不饱和脂肪酸与抑郁症之间的关联。
Association between plasma polyunsaturated fatty acids and depressive among US adults.
作者信息
Wang Man, Yan Xiaofang, Li Yanmei, Li Qian, Xu Yingxia, Huang Jitian, Gan Juan, Yang Wenhan
机构信息
Department of Nutrition and Food Health, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, Guangdong Province, China.
Department of Child and Adolescent Health, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, Guangdong Province, China.
出版信息
Front Nutr. 2024 Mar 13;11:1342304. doi: 10.3389/fnut.2024.1342304. eCollection 2024.
BACKGROUND
Depression is associated with greater functional impairment and high societal costs than many other mental disorders. Research on the association between plasma polyunsaturated fatty acids (PUFAs) levels and depression have yielded inconsistent results.
OBJECTIVE
To evaluate whether plasma n-3 and n-6 PUFAs levels are associated with depression in American adults.
METHODS
A cross-sectional study included 2053 adults (aged ≥20 y) in the National Health and Nutrition Examination Survey (NHANES), 2011-2012. The level of plasma n-3 and n-6 PUFAs were obtained for analysis. Self-reported Patient Health Questionnaire-9 (PHQ-9) was used to identify the depression status. Binary logistic regression analysis was performed to evaluate the association between quartiles of plasma n-3 and n-6 PUFAs and depression after adjustments for confounders.
RESULTS
The study of 2053 respondents over 20 years of age with a weighted depression prevalence of 7.29% comprised 1,043 men (weighted proportion, 49.13%) and 1,010 women (weighted, 50.87%), with a weighted mean (SE) age of 47.58 (0.67) years. Significantly increased risks of depression over non-depression were observed in the third quartiles (OR = 1.65, 95% CI = 1.05-2.62) for arachidonic acid (AA; 20:4n-6); the third quartiles (OR = 2.20, 95% CI = 1.20-4.05) for docosatetraenoic acid (DTA; 22:4n-6); the third (OR = 2.33, 95% CI = 1.34-4.07), and highest quartiles (OR = 1.83, 95% CI = 1.03-3.26) for docosapentaenoic acid (DPAn-6; 22:5n-6); and the third (OR = 2.18, 95% CI = 1.18-4.03) and highest quartiles (OR = 2.47, 95% CI = 1.31-4.68) for docosapentaenoic acid (DPAn-3; 22:5n-3); the second (OR = 2.13, 95% CI = 1.24-3.66), third (OR = 2.40, 95% CI = 1.28-4.50), and highest quartiles (OR = 2.24, 95% CI = 1.08-4.69) for AA/docosahexaenoic acid (DHA; 22:6n-3) ratio compared with the lowest quartile after adjusting for confounding factors.
CONCLUSION
Higher plasma levels of AA, DTA, DPAn-6, DPAn-3 PUFAs, and AA/DHA ratio may be potential risk factors for depression in US adults.
背景
与许多其他精神障碍相比，抑郁症与更严重的功能损害和高昂的社会成本相关。关于血浆多不饱和脂肪酸（PUFAs）水平与抑郁症之间关联的研究结果并不一致。
目的
评估美国成年人血浆n-3和n-6 PUFAs水平是否与抑郁症相关。
方法
一项横断面研究纳入了2011 - 2012年美国国家健康与营养检查调查（NHANES）中的2053名成年人（年龄≥20岁）。获取血浆n-3和n-6 PUFAs水平进行分析。采用自我报告的患者健康问卷-9（PHQ-9）来确定抑郁状态。进行二元逻辑回归分析，以评估在调整混杂因素后血浆n-3和n-6 PUFAs四分位数与抑郁症之间的关联。
结果
该研究对2053名20岁以上的受访者进行了调查，加权抑郁患病率为7.29%，其中包括1043名男性（加权比例为49.13%）和1010名女性（加权比例为50.87%），加权平均（SE）年龄为47.58（0.67）岁。在调整混杂因素后，与最低四分位数相比，花生四烯酸（AA；20:4n-6）的第三四分位数（OR = 1.65，95%CI = 1.05 - 2.62）、二十二碳四烯酸（DTA；22:4n-6）的第三四分位数（OR = 2.20，95%CI = 1.20 - 4.05）、二十二碳五烯酸（DPAn-6；22:5n-6）的第三四分位数（OR = 2.33，95%CI = 1.34 - 4.07）和最高四分位数（OR = 1.83，95%CI = 1.03 - 3.26）、二十二碳五烯酸（DPAn-3；22:5n-3）的第三四分位数（OR = 2.18，95%CI = 1.18 - 4.03）和最高四分位数（OR = 2.47，95%CI = 1.31 - 4.68），以及AA/二十二碳六烯酸（DHA；22:6n-3）比值的第二四分位数（OR = 2.13，95%CI = 1.24 - 3.66）、第三四分位数（OR = 2.40，95%CI = 1.28 - 4.50）和最高四分位数（OR = 2.24，95%CI = 1.08 - 4.69）的抑郁症风险显著高于非抑郁症。
结论
较高的血浆AA、DTA、DPAn-6、DPAn-3 PUFAs水平以及AA/DHA比值可能是美国成年人患抑郁症的潜在风险因素。
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