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-（2-氨基苯甲酰基）苯并三唑介导的3-酰基-2-烷基（芳基）-4-羟基喹啉和3-酰基氨基-4（3）喹唑啉酮的合成

-(2-Aminobenzoyl)benzotriazole Mediated Synthesis of 3-Acyl-2-alkyl(aryl)-4-hydroxyquinolines and 3-Acylamino-4(3) quinazolinones.

作者信息

Şenol İlbilge Merve, Gökbulut Satioğlu Sevtem, Çelik İlhami

机构信息

Department of Chemistry, Faculty of Science, Eskişehir Technical University, Eskişehir, Turkiye.

出版信息

Turk J Chem. 2023 Oct 16;48(1):97-107. doi: 10.55730/1300-0527.3642. eCollection 2024.

DOI:10.55730/1300-0527.3642
PMID:38544903
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10965190/
Abstract

New methods have been developed for the synthesis of the substituted quinolines and quinazolinones derivatives by utilizing -(2-aminobenzoyl)benzotriazoles under mild reaction conditions. 3-Acyl-2-alkyl(aryl)-4-hydroxyquinolines were obtained in modarete yields by the reaction of -(2-aminobenzoyl)benzotriazoles and diketones in the presence of -BuOK. 3-Acylamino-4(3) quinazolinones were obtained in good yields via -(2-aminobenzoyl)benzotriazoles, orthoester and hyrazides in one-pot.

摘要

已经开发出了新的方法，可在温和的反应条件下利用-(2-氨基苯甲酰基)苯并三唑来合成取代喹啉和喹唑啉酮衍生物。在叔丁醇钾存在的情况下，通过-(2-氨基苯甲酰基)苯并三唑与二酮反应，以中等产率获得了3-酰基-2-烷基(芳基)-4-羟基喹啉。通过一锅法，由-(2-氨基苯甲酰基)苯并三唑、原酸酯和酰肼以良好的产率获得了3-酰基氨基-4(3)喹唑啉酮。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1fc/10965190/9585f614092a/tjc-48-01-0097f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1fc/10965190/bbefd82f02a7/tjc-48-01-0097f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1fc/10965190/6e2d3b32e477/tjc-48-01-0097f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1fc/10965190/c9b7eb49b380/tjc-48-01-0097f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1fc/10965190/1511fde44820/tjc-48-01-0097f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1fc/10965190/527858e62d66/tjc-48-01-0097f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1fc/10965190/5581b5aae794/tjc-48-01-0097f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1fc/10965190/881aba22322f/tjc-48-01-0097f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1fc/10965190/9585f614092a/tjc-48-01-0097f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1fc/10965190/bbefd82f02a7/tjc-48-01-0097f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1fc/10965190/6e2d3b32e477/tjc-48-01-0097f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1fc/10965190/c9b7eb49b380/tjc-48-01-0097f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1fc/10965190/1511fde44820/tjc-48-01-0097f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1fc/10965190/527858e62d66/tjc-48-01-0097f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1fc/10965190/5581b5aae794/tjc-48-01-0097f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1fc/10965190/881aba22322f/tjc-48-01-0097f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1fc/10965190/9585f614092a/tjc-48-01-0097f8.jpg

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本文引用的文献

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New Anti SARS-Cov-2 Targets for Quinoline Derivatives Chloroquine and Hydroxychloroquine.新型抗 SARS-CoV-2 靶点：氯喹和羟氯喹的喹啉衍生物。
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