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用于骨科应用的明胶基材料的生物打印

Bioprinting of gelatin-based materials for orthopedic application.

作者信息

Waidi Yusuf Olatunji, Kariim Ishaq, Datta Sudipto

机构信息

Indian Institute of Science (IISc), Bangalore, India.

Nelson Mandela African Institution of Science and Technology, Arusha, Tanzania.

出版信息

Front Bioeng Biotechnol. 2024 Mar 13;12:1357460. doi: 10.3389/fbioe.2024.1357460. eCollection 2024.

DOI:10.3389/fbioe.2024.1357460
PMID:38544981
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10966130/
Abstract

Bio-printed hydrogels have evolved as one of the best regenerative medicine and tissue engineering platforms due to their outstanding cell-friendly microenvironment. A correct hydrogel ink formulation is critical for creating desired scaffolds that have better fidelity after printing. Gelatin and its derivatives have sparked intense interest in various biomedical sectors because of their biocompatibility, biodegradability, ease of functionalization, and rapid gelling tendency. As a result, this report emphasizes the relevance of gelatin-based hydrogel in fabricating bio-printed scaffolds for orthopedic applications. Starting with what hydrogels and bio-printing are all about. We further summarized the different gelatin-based bio-printing techniques explored for orthopedic applications, including a few recent studies. We also discussed the suitability of gelatin as a biopolymer for both 3D and 4D printing materials. As extrusion is one of the most widely used techniques for bio-printing gelatin-based, we summarize the rheological features of gelatin-based bio-ink. Lastly, we also elaborate on the recent bio-printed gelatin-based studies for orthopedics applications, the potential clinical translation issues, and research possibilities.

摘要

由于其出色的细胞友好型微环境，生物打印水凝胶已发展成为最佳的再生医学和组织工程平台之一。正确的水凝胶油墨配方对于制造在打印后具有更好保真度的理想支架至关重要。明胶及其衍生物因其生物相容性、生物降解性、易于功能化和快速凝胶化趋势而在各个生物医学领域引起了浓厚兴趣。因此，本报告强调了基于明胶的水凝胶在制造用于骨科应用的生物打印支架中的相关性。首先介绍水凝胶和生物打印的概念。我们进一步总结了为骨科应用探索的不同的基于明胶的生物打印技术，包括一些近期研究。我们还讨论了明胶作为生物聚合物用于3D和4D打印材料的适用性。由于挤出是生物打印基于明胶材料最广泛使用的技术之一，我们总结了基于明胶的生物墨水的流变学特征。最后，我们还阐述了近期用于骨科应用的基于明胶的生物打印研究、潜在的临床转化问题和研究可能性。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e16/10966130/69455c02ae55/fbioe-12-1357460-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e16/10966130/bc8795ae7d41/fbioe-12-1357460-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e16/10966130/81b3d9d32ab3/fbioe-12-1357460-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e16/10966130/f61f0bfe6e8e/fbioe-12-1357460-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e16/10966130/57a070cc8a6d/fbioe-12-1357460-g012.jpg

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