Division of Hematology, Oncology, and Transplantation, Department of Medicine, Masonic Cancer Center, University of Minnesota, Minneapolis, MN, United States.
Front Immunol. 2024 Mar 11;15:1356666. doi: 10.3389/fimmu.2024.1356666. eCollection 2024.
Enhancing the cytotoxicity of natural killer (NK) cells has emerged as a promising strategy in cancer immunotherapy, due to their pivotal role in immune surveillance and tumor clearance. This literature review provides a comprehensive overview of therapeutic approaches designed to augment NK cell cytotoxicity. We analyze a wide range of strategies, including cytokine-based treatment, monoclonal antibodies, and NK cell engagers, and discuss criteria that must be considered when selecting an NK cell product to combine with these strategies. Furthermore, we discuss the challenges and limitations associated with each therapeutic strategy, as well as the potential for combination therapies to maximize NK cell cytotoxicity while minimizing adverse effects. By exploring the wealth of research on this topic, this literature review aims to provide a comprehensive resource for researchers and clinicians seeking to develop and implement novel therapeutic strategies that harness the full potential of NK cells in the fight against cancer. Enhancing NK cell cytotoxicity holds great promise in the evolving landscape of immunotherapy, and this review serves as a roadmap for understanding the current state of the field and the future directions in NK cell-based therapies.
增强自然杀伤 (NK) 细胞的细胞毒性已成为癌症免疫疗法中一种很有前途的策略，因为 NK 细胞在免疫监视和肿瘤清除中发挥着关键作用。本文综述提供了增强 NK 细胞细胞毒性的治疗方法的全面概述。我们分析了广泛的策略，包括细胞因子治疗、单克隆抗体和 NK 细胞激活剂，并讨论了在选择与这些策略结合使用的 NK 细胞产品时必须考虑的标准。此外，我们还讨论了每种治疗策略相关的挑战和局限性，以及联合治疗的潜力，以最大程度地提高 NK 细胞的细胞毒性，同时最小化不良反应。通过探索这个主题的丰富研究，本综述旨在为寻求开发和实施利用 NK 细胞在癌症治疗中的全部潜力的新型治疗策略的研究人员和临床医生提供一个全面的资源。增强 NK 细胞的细胞毒性在免疫疗法的不断发展的格局中具有巨大的潜力，本综述为理解该领域的现状和 NK 细胞治疗的未来方向提供了路线图。
