Du Nan, Bao Lei, Zhang Jing, Li Xiaowen, Tian Jin, Xia Man, Chen Wei, Zhu Pinyi, Sun XiuJuan, Wang Min, Wu Yihan, He Lin, Gao Yang, Sun Wen, Zhang Zunsheng, Chen Hao
Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China.
Department of Neurology, Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China.
Heliyon. 2024 Mar 16;10(6):e27953. doi: 10.1016/j.heliyon.2024.e27953. eCollection 2024 Mar 30.
The neutrophil-to-lymphocyte ratio (NLR) is a widely recognized marker of inflammation in peripheral blood. However, its specific role in neuronal intranuclear inclusion disease (NIID) has not been reported. This study aims to investigate the relationship between NIID and NLR.
A multicenter database was collected, including 157 NIID patients from seven hospitals (The Affiliated Hospital of Xuzhou Medical University, Yantai Yuhuangding Hospital, Tengzhou Central People's Hospital,The Affiliated Brain Hospital of Nanjing Medical University, Liaocheng People's Hospital,The Second Hospital of Shandong University, Inner Mongolia People's Hospital, Xuanwu Hospital Capital Medical University,The First Affiliated Hospital of USTC), along with 157 age- and gender-matched healthy control subjects. White blood cell counts (including neutrophils, lymphocytes, monocytes, eosinophils, and basophils) were obtained, and the NLR was calculated. Additionally, cognitive impairment was assessed using clinical evaluation scores.
NIID patients exhibited significantly higher NLR values compared to the healthy control group (p < 0.001). The plasma NLR levels in NIID patients showed a weak positive correlation with disease duration (r = 0.219, p = 0.016). However, no significant correlations were found between NLR and age of onset or cognitive impairment (p > 0.05).
There is a significant association between NLR and NIID, suggesting a potential role of peripheral blood inflammation in the pathogenesis of NIID.
中性粒细胞与淋巴细胞比值（NLR）是外周血中广泛认可的炎症标志物。然而，其在神经元核内包涵体病（NIID）中的具体作用尚未见报道。本研究旨在探讨NIID与NLR之间的关系。
收集了一个多中心数据库，包括来自七家医院（徐州医科大学附属医院、烟台毓璜顶医院、滕州中心人民医院、南京医科大学附属脑科医院、聊城市人民医院、山东大学第二医院、内蒙古自治区人民医院、首都医科大学宣武医院、中国科学技术大学附属第一医院）的157例NIID患者，以及157名年龄和性别匹配的健康对照者。获取白细胞计数（包括中性粒细胞、淋巴细胞、单核细胞、嗜酸性粒细胞和嗜碱性粒细胞），并计算NLR。此外，使用临床评估评分评估认知障碍。
与健康对照组相比，NIID患者的NLR值显著更高（p < 0.001）。NIID患者的血浆NLR水平与病程呈弱正相关（r = 0.219，p = 0.016）。然而，未发现NLR与发病年龄或认知障碍之间存在显著相关性（p > 0.05）。
NLR与NIID之间存在显著关联，提示外周血炎症在NIID发病机制中可能起作用。
