Department of Neurology, the Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, 1 Huanghe Road West, Huaian, 223300, Jiangsu, China.
BMC Neurol. 2024 Oct 8;24(1):379. doi: 10.1186/s12883-024-03887-7.
Peripheral immunity and neuroinflammation interact with each other and they play important roles in the pathophysiology of idiopathic Parkinson's disease (IPD). There have been very few real-world reports on the relationship between peripheral immune inflammation and motor phenotypes of IPD. This study aimed to investigate the potential correlation between peripheral inflammatory indicators and motor subtypes in patients with IPD.
This observational, prospective case-control study examined patients with IPD and healthy controls (HC) matched for age and sex between September 2021 and July 2023 at the Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University. The levels of peripheral inflammatory indicators were collected from each patient with IPD and HCs. Differences in the levels of peripheral inflammatory indicators among groups were compared. Binary logistic regression analysis was used to explore the inflammatory mechanism underlying the motor subtype of IPD.
A total number of 94 patients with IPD were recruited at the Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University between September 2021 and July 2023, including 49 males and 45 females, and 37 healthy volunteers matched for age and sex were also enrolled as the control group. Of the 94 patients with IPD, 42.6% performed as the TD motor subtype and 57.4% performed as the AR motor subtype. NLR and the plasma levels of IL-1βand TNF-α in the IPD group were higher than those in the HC group (P < 0.05). The disease duration, Hoehn and Yahr (H-Y) stage, NLR, and the levels of IL-1β in the AR group were higher than those in the TD group (P < 0.05). Additionally, IL-1β plasma levels and NLR were positively correlated with disease duration, H-Y stage, movement disorder society-Unified Parkinson's Disease Rating Scale-III motor score, and AR subtype. The binary logistic regression model revealed that the plasma level of IL-1β was mildly associated with the AR motor subtype and NLR was strongly associated with the AR motor subtype. The combination of NLR and IL-1β showed better performance in identifying the AR motor subtype.
NLR is strongly associated with the AR motor subtype in IPD, and peripheral immunity is probably involved in the pathogenesis of AR motor subtype in IPD.
外周免疫与神经炎症相互作用，在特发性帕金森病（IPD）的病理生理学中发挥重要作用。很少有真实世界的报告研究 IPD 的外周免疫炎症与运动表型之间的关系。本研究旨在探讨 IPD 患者外周炎症指标与运动亚型之间的潜在相关性。
本研究为观察性、前瞻性病例对照研究，于 2021 年 9 月至 2023 年 7 月在南京医科大学附属淮安第一人民医院纳入 IPD 患者和健康对照者（HC），并按年龄和性别匹配。从每位 IPD 患者和 HC 中收集外周炎症指标水平。比较各组间外周炎症指标水平的差异。采用二元逻辑回归分析探讨 IPD 运动亚型的炎症机制。
共纳入南京医科大学附属淮安第一人民医院 2021 年 9 月至 2023 年 7 月的 94 例 IPD 患者，其中男 49 例，女 45 例，同时纳入年龄和性别匹配的 37 例健康志愿者作为对照组。94 例 IPD 患者中，42.6%表现为 TD 运动亚型，57.4%表现为 AR 运动亚型。IPD 组 NLR 和白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）的血浆水平高于 HC 组（P<0.05）。AR 组的病程、Hoehn 和 Yahr（H-Y）分期、NLR 和 IL-1β水平均高于 TD 组（P<0.05）。此外，IL-1β血浆水平和 NLR 与病程、H-Y 分期、运动障碍协会-统一帕金森病评定量表-III 运动评分和 AR 亚型呈正相关。二元逻辑回归模型显示，IL-1β的血浆水平与 AR 运动亚型轻度相关，NLR 与 AR 运动亚型高度相关。NLR 和 IL-1β的组合在识别 AR 运动亚型方面表现更好。
NLR 与 IPD 中的 AR 运动亚型强烈相关，外周免疫可能参与了 IPD 中 AR 运动亚型的发病机制。
