Allende Santiago, Mahoney Louise, Francisco Jasmin M, Fitz Korrine, Keaney Audrey, Parker-Bridges Kelly, Mahoney Heidi, Jo Booil, Greenberg Jason, Bayley Peter J
War Related Illness and Injury Study Center, VA Palo Alto Health Care System, Palo Alto, CA, USA.
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Glob Adv Integr Med Health. 2024 Mar 26;13:27536130241240405. doi: 10.1177/27536130241240405. eCollection 2024 Jan-Dec.
Chronic musculoskeletal pain is common in patients with Alzheimer's disease (AD), and there is growing awareness that chronic pain has an impact on the progression of dementia. Yoga has shown promise in treating chronic pain. However, attending in-person yoga can be difficult for AD patients.
To assess the feasibility, acceptability and preliminary efficacy of an online yoga (teleyoga) protocol suitable for AD patients with chronic pain, and their caregivers.
Patients with comorbid mild AD and chronic musculoskeletal pain ( = 15, 57-95 y/o; 73% Female) and their caregivers ( = 15, 50-75 y/o; 67% Female) received 12-week of teleyoga individually ( = 5 dyads) or in groups ( = 10 dyads). Study measures included standard feasibility metrics, and secondary outcomes included the Brief Pain Inventory-Short Form (BPI-SF), Beck Depression Inventory-II (BDI-II), and cognitive function using the Cambridge Neuropsychological Test Automated Battery (CANTAB). Caregivers also completed measures of caregiver burden, and quality of life (Short Form Health Survey-36, SF-36).
Feasibility measures showed adequate treatment adherence (85.1% in patients and 86.3% in caregivers), acceptability (mean acceptability rating = 3.0 for patients and 3.3 for caregivers, indicating positive approval), recruitment rate ( = 16 dyads within 1-year), retention rate (87%), missing data rate (.03%), and fidelity of treatment delivery (87%). Preliminary efficacy findings in the AD group showed significant reductions in pain severity (BPI-SF mean Δ = -.93, .045) and depression (BDI-II; mean Δ = -9.85, .005). %). Preliminary efficacy findings in the caregiver group showed significant reductions in depression (BDI-II mean Δ = -6.88, .036) and fatigue (SF-36 mean Δ = 9.81, .021).
Results show that teleyoga is a feasible treatment for patients with comorbid mild AD and chronic musculoskeletal pain. Results also provide preliminary evidence of health benefits of teleyoga for both AD patients and their caregivers.
慢性肌肉骨骼疼痛在阿尔茨海默病（AD）患者中很常见，并且人们越来越意识到慢性疼痛会对痴呆症的进展产生影响。瑜伽已显示出治疗慢性疼痛的前景。然而，对于AD患者来说，参加面对面的瑜伽课程可能会有困难。
评估适合患有慢性疼痛的AD患者及其护理人员的在线瑜伽（远程瑜伽）方案的可行性、可接受性和初步疗效。
患有轻度AD合并慢性肌肉骨骼疼痛的患者（n = 15，年龄57 - 95岁；73%为女性）及其护理人员（n = 15，年龄50 - 75岁；67%为女性）分别（n = 5对）或分组（n = 10对）接受为期12周的远程瑜伽课程。研究指标包括标准可行性指标，次要结局包括简明疼痛量表简表（BPI - SF）、贝克抑郁量表第二版（BDI - II），以及使用剑桥神经心理测试自动成套系统（CANTAB）评估的认知功能。护理人员还完成了护理负担和生活质量的测量（健康调查简表36，SF - 36）。
可行性指标显示治疗依从性良好（患者为85.1%，护理人员为86.3%）、可接受性（患者的平均可接受评分为3.0，护理人员为3.3，表明积极认可）、招募率（在一年内有16对）、保留率（87%）、数据缺失率（0.03%）以及治疗实施的保真度（87%）。AD组的初步疗效结果显示疼痛严重程度显著降低（BPI - SF平均变化量Δ = -0.93，P <.045）和抑郁（BDI - II；平均变化量Δ = -9.85，P <.005）。护理人员组的初步疗效结果显示抑郁显著降低（BDI - II平均变化量Δ = -6.88，P <.036）和疲劳（SF - 36平均变化量Δ = 9.81，P <.021）。
结果表明，远程瑜伽对于患有轻度AD合并慢性肌肉骨骼疼痛的患者是一种可行的治疗方法。结果还为远程瑜伽对AD患者及其护理人员的健康益处提供了初步证据。
