Alvarado-Valdivia Nataly T, Flores Juan A, Inolopú Jorge L, Rosales-Rimache Jaime A
Escuela Profesional de Tecnología Médica, Universidad Privada de Tacna., Tacna 23001, Peru.
Escuela Profesional de Tecnología Médica, Universidad Privada San Juan Bautista., Lima 15067, Peru.
J Clin Tuberc Other Mycobact Dis. 2024 Mar 16;35:100432. doi: 10.1016/j.jctube.2024.100432. eCollection 2024 May.
The role played by type 2 diabetes mellitus (DM2) in the occurrence of recurrent tuberculosis is still uncertain. Military personnel are an occupational group with an increased risk for tuberculosis exposure due to their activities. We conducted a retrospective cohort to study the association between DM2 and recurrent TB in military workers who have been previously treated for tuberculosis at the Central Military Hospital in Lima, Peru, between 2016 and 2017. We evaluated the risk between DM2 and recurrent TB using Nelson-Aalen graphical analysis and Cox regression stratified by TB cured with hazard ratio (HR) calculation adjusted for confounders. We evaluated 220 workers with a mean age of 23.2 ± 7.8 years (96.8 % male). DM2 and recurrent TB frequency were 11.8 % and 5.0 %, respectively. Those with DM (36.5 %) presented a greater proportion of recurrent TB than those without DM2 (10.5 %). The cumulative risk for recurrent TB increases faster among workers with DM2 (p = 0.025, LR chi-squared test). Cox regression stratified by type of cured TB did not show an association between DM2 and recurrent TB (HR: 3.67; 95 %CI: 1.00-13.46). The cumulative risk for recurrent TB increases faster in patients with DM than in those without DM2. DM2 is not associated with the time of apparition of recurrent TB in military workers.
2型糖尿病（DM2）在复发性结核病发生中所起的作用仍不确定。军事人员是一个职业群体，因其活动导致接触结核病的风险增加。我们进行了一项回顾性队列研究，以探讨2016年至2017年期间在秘鲁利马中央军事医院接受过结核病治疗的军事人员中DM2与复发性结核病之间的关联。我们使用Nelson-Aalen图形分析和Cox回归评估DM2与复发性结核病之间的风险，并按结核病治愈情况分层，计算风险比（HR）并对混杂因素进行调整。我们评估了220名工人，平均年龄为23.2±7.8岁（96.8%为男性）。DM2和复发性结核病的发生率分别为11.8%和5.0%。患有糖尿病的人（36.5%）复发性结核病的比例高于未患DM2的人（10.5%）。DM2患者复发性结核病的累积风险增加得更快（p = 0.025，似然比卡方检验）。按治愈结核病类型分层的Cox回归未显示DM2与复发性结核病之间存在关联（HR：3.67；95%CI：1.00 - 13.46）。糖尿病患者复发性结核病的累积风险比未患DM2的患者增加得更快。DM2与军事人员复发性结核病的出现时间无关。
