多酚对 tau 液-液相分离的双相调节。
Biphasic modulation of tau liquid-liquid phase separation by polyphenols.
机构信息
Bioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bengaluru 560064, Karnataka, India.
出版信息
Chem Commun (Camb). 2024 Apr 16;60(32):4334-4337. doi: 10.1039/d4cc00473f.
PMID:38545836
Abstract
Molecular tools that modulate tau liquid-liquid phase separation (LLPS) promise to treat tauopathies. We screened a set of polyphenols and demonstrated concentration-dependent biphasic modulation of tau LLPS by gallic acid (GA), showcasing its ability to expedite the liquid-to-gel transition in tau condensates and effectively impede the formation of deleterious fibrillar aggregates.
摘要
分子工具可调节 tau 液-液相分离（LLPS），有望治疗 tau 病。我们筛选了一组多酚，并证实了没食子酸（GA）对 tau LLPS 的浓度依赖性双相调节，展示了其促进 tau 凝聚物从液相到凝胶相转变的能力，并有效阻止有害纤维状聚集体的形成。
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