Bioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bengaluru 560064, Karnataka, India.
Chem Commun (Camb). 2024 Apr 16;60(32):4334-4337. doi: 10.1039/d4cc00473f.
Molecular tools that modulate tau liquid-liquid phase separation (LLPS) promise to treat tauopathies. We screened a set of polyphenols and demonstrated concentration-dependent biphasic modulation of tau LLPS by gallic acid (GA), showcasing its ability to expedite the liquid-to-gel transition in tau condensates and effectively impede the formation of deleterious fibrillar aggregates.
分子工具可调节 tau 液-液相分离（LLPS），有望治疗 tau 病。我们筛选了一组多酚，并证实了没食子酸（GA）对 tau LLPS 的浓度依赖性双相调节，展示了其促进 tau 凝聚物从液相到凝胶相转变的能力，并有效阻止有害纤维状聚集体的形成。
