妇产科中前列腺素的一些临床和理论方面
Some clinical and theoretical aspects on prostaglandins in obstetrics and gynecology.
作者信息
Wiqvist N, Wilhelmsson L
出版信息
Gynecol Obstet Invest. 1979;10(1):1-8. doi: 10.1159/000299912.
The present article discusses two aspects on prostaglandins, both related to the control of uterine contractility. One concerns a clinical problem, induction of abortion, and argues in favor of systemic instead of intrauterine administration of prostaglandins and the choice of E instead of F analogues. The other relates to the stimulatory effect on the myometrium of some recently detected endogenous prostaglandins. The discussion regarding the endogenous control of myometrial contractility has so far exclusively been focused upon the classical prostaglandins. It is, however, felt that substances like PGH2, PGI2 and thromboxane A2 may play a significant role in the regulation of uterine activity.
本文讨论了前列腺素的两个方面，均与子宫收缩的控制有关。一方面涉及一个临床问题，即人工流产引产，并主张前列腺素采用全身给药而非宫腔内给药，以及选择E类而非F类类似物。另一方面涉及一些最近发现的内源性前列腺素对子宫肌层的刺激作用。迄今为止，关于子宫肌层收缩的内源性控制的讨论一直仅集中在经典的前列腺素上。然而，人们认为诸如PGH2、PGI2和血栓素A2等物质可能在子宫活动的调节中发挥重要作用。
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