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分娩过程中人类羊水内存在血小板活化因子（1-0-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱）的质谱分析证据。

Mass spectrometric evidence for the presence of platelet-activating factor (1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in human amniotic fluid during labor.

作者信息

Nishihira J, Ishibashi T, Imai Y, Muramatsu T

出版信息

Lipids. 1984 Dec;19(12):907-10. doi: 10.1007/BF02534724.

DOI:10.1007/BF02534724
PMID:6527609
Abstract

Evidence is presented for the existence of platelet-activating factor (PAF) in human amniotic fluid during labor by gas-liquid chromatographic (GLC) and mass-spectrometric (MS) analysis. The unique ether-linked phospholipid was identified only in an amniotic fluid obtained from women during labor, and its alkyl side chain was composed exclusively of octadecyl residue.

摘要

通过气液色谱（GLC）和质谱（MS）分析，证实了分娩过程中人类羊水存在血小板活化因子（PAF）。这种独特的醚键连接磷脂仅在分娩期间从女性获得的羊水中被鉴定出来，其烷基侧链仅由十八烷基残基组成。

相似文献

1
Mass spectrometric evidence for the presence of platelet-activating factor (1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in human amniotic fluid during labor.分娩过程中人类羊水内存在血小板活化因子（1-0-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱）的质谱分析证据。
Lipids. 1984 Dec;19(12):907-10. doi: 10.1007/BF02534724.
2
Identification of phospholipid platelet-activating factor (1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in human amniotic fluid and urine.人羊水和尿液中磷脂血小板激活因子（1-0-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱）的鉴定。
Biochem Biophys Res Commun. 1983 May 31;113(1):51-8. doi: 10.1016/0006-291x(83)90430-8.
3
Detection of platelet-activating factor in amniotic fluid of complicated pregnancies.复杂妊娠孕妇羊水血小板活化因子的检测
Am J Obstet Gynecol. 1990 Feb;162(2):525-8. doi: 10.1016/0002-9378(90)90423-5.
4
Production and characterization of specific antibodies against 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a potent hypotensive and platelet-activating ether-linked phospholipid).针对1-O-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱（一种强效降压和血小板激活的醚连接磷脂）的特异性抗体的制备与表征
J Biochem. 1984 May;95(5):1247-51. doi: 10.1093/oxfordjournals.jbchem.a134728.
5
Characterization and quantification of PAF-acether (platelet-activating factor) as a heptafluorobutyrate derivative of 1-O-alkyl-2-acetyl-sn-glycerol by capillary column gas chromatography with electron-capture detection.
J Chromatogr. 1987 Dec 25;423:23-31. doi: 10.1016/0378-4347(87)80324-9.
6
Metabolism of platelet activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) and 1-alkyl-2-acetyl-sn-glycerol by human endothelial cells.人内皮细胞对血小板活化因子（1-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱）和1-烷基-2-乙酰基-sn-甘油的代谢
Biochim Biophys Acta. 1986 May 21;876(3):373-8. doi: 10.1016/0005-2760(86)90022-6.
7
Platelet-activating factor metabolism in human amnion and the responses of this tissue to extracellular platelet-activating factor.
Prostaglandins. 1985 Nov;30(5):841-50. doi: 10.1016/0090-6980(85)90012-7.
8
Metabolism of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in human fetal membranes and decidua vera.人胎膜和真蜕膜中血小板活化因子（1-O-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱）的代谢
Arch Biochem Biophys. 1986 Apr;246(1):9-18. doi: 10.1016/0003-9861(86)90444-3.
9
Quantitation of lyso-platelet activating factor molecular species from human neutrophils by mass spectrometry.
J Lipid Res. 1987 Jan;28(1):42-9.
10
A Penicillium sp. F33 metabolite and its synthetic derivatives inhibit acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and carrageenan-induced paw edema in mice.青霉属 F33 代谢产物及其合成衍生物抑制乙酰辅酶 A：1-O- 烷基- sn-甘油-3-磷酸胆碱乙酰转移酶（血小板激活因子生物合成的关键酶）和角叉菜胶诱导的小鼠足肿胀。
Biochem Pharmacol. 2013 Sep 1;86(5):632-44. doi: 10.1016/j.bcp.2013.06.021. Epub 2013 Jun 28.

引用本文的文献

1
Activation of protein kinase C inhibits the secretion of platelet-activating factor acetylhydrolase by human decidual macrophages.蛋白激酶C的激活抑制人蜕膜巨噬细胞分泌血小板活化因子乙酰水解酶。
Reprod Med Biol. 2003 Sep 26;2(3):121-126. doi: 10.1046/j.1445-5781.2003.00032.x. eCollection 2003 Sep.
2
Platelet-activating factor: a role in preterm delivery and an essential interaction with Toll-like receptor signaling in mice.血小板活化因子：在早产中的作用以及与小鼠Toll样受体信号传导的重要相互作用。
Biol Reprod. 2014 Nov;91(5):119. doi: 10.1095/biolreprod.113.116012. Epub 2014 Sep 24.
3
Lipopolysaccharide induces nitric oxide synthase expression and platelet-activating factor increases nitric oxide production in human fetal membranes in culture.

本文引用的文献

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REMOVAL AND METABOLISM OF TRIGLYCERIDES BY PERFUSED LIVER.灌注肝脏对甘油三酯的清除与代谢
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Platelet-activating factor acetylhydrolase activity in maternal, fetal, and newborn rabbit plasma during pregnancy and lactation.妊娠和哺乳期母兔、胎兔及新生兔血浆中血小板活化因子乙酰水解酶活性
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Synthesis of platelet activating factor by cholinephosphotransferase in developing fetal rabbit lung.
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The hormonal regulation of platelet-activating factor acetylhydrolase activity in plasma.血浆中血小板活化因子乙酰水解酶活性的激素调节
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Stereospecific activity of 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine and comparison of analogs in the degranulation of platelets and neutrophils.1-O-烷基-2-O-乙酰基-sn-甘油-3-磷酸胆碱的立体特异性活性及其类似物在血小板和中性粒细胞脱颗粒中的比较。
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Potent platelet stimulating activity of enantiomers of acetyl glyceryl ether phosphorylcholine and its methoxy analogues.乙酰甘油醚磷酸胆碱及其甲氧基类似物对映体的强效血小板刺激活性。
Biochem Biophys Res Commun. 1981 Mar 16;99(1):183-8. doi: 10.1016/0006-291x(81)91730-7.
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Modification of the polar head group of acetyl glyceryl ether phosphorylcholine and subsequent effects upon platelet activation.乙酰甘油醚磷酸胆碱极性头部基团的修饰及其对血小板活化的后续影响。
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Antihypertensive lipids from the kidney: alkyl ether analogs of phosphatidylcholine.来自肾脏的抗高血压脂质：磷脂酰胆碱的烷基醚类似物。
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Platelet activating factor. Stimulation of the lipoxygenase pathway in polymorphonuclear leukocytes by 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine.血小板活化因子。1-O-烷基-2-O-乙酰基-sn-甘油-3-磷酸胆碱对多形核白细胞中脂氧合酶途径的刺激作用。
J Biol Chem. 1982 May 25;257(10):5402-7.
10
Production and characterization of specific antibodies against 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a potent hypotensive and platelet-activating ether-linked phospholipid).针对1-O-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱（一种强效降压和血小板激活的醚连接磷脂）的特异性抗体的制备与表征
J Biochem. 1984 May;95(5):1247-51. doi: 10.1093/oxfordjournals.jbchem.a134728.