水松酮 A，一种具有独特骨架的来自水松的细胞毒 C 型三萜。
Taxodin A, a Cytotoxic C Terpenoid from Taxodium mucronatum with a Unique Skeleton.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 650201, Kunming, People's Republic of China.
University of Chinese Academy of Sciences, 100049, Beijing, People's Republic of China.
出版信息
Chem Biodivers. 2024 May;21(5):e202400648. doi: 10.1002/cbdv.202400648. Epub 2024 Apr 22.
Taxodin A (1), a unique C terpenoid featuring an unprecedented skeleton composed of an abietane-type diterpene and a menthane-type monoterpene, was obtained from the leaves and branches of Taxodium mucronatum. The structure and absolute configuration of compound 1 was unequivocally established by the combination of extensive spectroscopic analyses and X-ray single-crystal diffraction analysis. Compound 1 exhibited potent cytotoxic activities against A549, SMMC-7721, MDA-MB-231, and SW480 cell lines with IC values of 15.35±0.73, 8.49±0.35, 17.53±0.79, 18.93±0.60 μM, respectively.
从落羽杉的叶和枝中分离得到 Taxodin A（1），这是一种独特的 C 萜类化合物，具有前所未有的骨架，由一个松香烷型二萜和一个薄荷烷型单萜组成。通过广泛的光谱分析和 X 射线单晶衍射分析的结合，明确确定了化合物 1 的结构和绝对构型。化合物 1 对 A549、SMMC-7721、MDA-MB-231 和 SW480 细胞系表现出强烈的细胞毒性活性，IC 值分别为 15.35±0.73、8.49±0.35、17.53±0.79、18.93±0.60 μM。
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