Abibalsamins A 和 B，两种来自加拿大香脂冷杉松脂的四萜类化合物。

Abibalsamins A and B, two new tetraterpenoids from Abies balsamea oleoresin.

机构信息

Université du Québec à Chicoutimi, Laboratoire d'Analyse et de Séparation des Essences Végétales (LASEVE), Département des Sciences Fondamentales, 555 boul. de l'Université, Chicoutimi (Québec), Canada, G7H 2B1.

出版信息

Org Lett. 2012 Mar 16;14(6):1504-7. doi: 10.1021/ol300237f. Epub 2012 Mar 7.

DOI:10.1021/ol300237f

PMID:22394397

Abstract

Abibalsamins A (1) and B (2), two unprecedented tetraterpenoids featuring a 3,4-seco-rearranged lanostane system fused with a β-myrcene lateral chain via a [4 + 2] Diels-Alder cycloaddition, were isolated from the oleoresin of Abies balsamea. Their structures were elucidated by means of extensive 2D NMR, IR, and MS spectroscopy analyses. The absolute configuration of 1 was determined by single-crystal X-ray diffraction. Both compounds exhibited significant cytotoxic activity against cancer cell lines.

摘要

阿比巴尔萨明 A（1）和 B（2），两种前所未有的四萜类化合物，具有通过[4 + 2] Diels-Alder 环加成反应连接的 3,4-裂环 rearranged 羊毛甾烷系统和 β-月桂烯侧链，从加拿大香脂树脂中分离得到。通过广泛的 2D NMR、IR 和 MS 光谱分析阐明了它们的结构。通过单晶 X 射线衍射确定了 1 的绝对构型。这两种化合物对癌细胞系均具有显著的细胞毒性活性。