饮酒与骨密度的关系：来自 NHANES 2005-2020 及双样本 Mendelian 随机化研究的结果。
Association between alcohol intake and bone mineral density: results from the NHANES 2005-2020 and two-sample Mendelian randomization.
机构信息
Department of Orthopedics, Changzheng Hospital, Second Military Medical University, Shanghai, China.
出版信息
Arch Osteoporos. 2024 Mar 28;19(1):21. doi: 10.1007/s11657-024-01382-7.
UNLABELLED
We used the data from the NHANES cross-sectional study among 14,113 participants and indicated a positive correlation between alcohol intake frequency and bone mineral density in different body sites. Mendelian randomization was conducted, and no causal relationship is significant between these two variables. The study can provide some suggestions on the daily consumption of alcohol for osteoporosis patients.
PURPOSE
The effect of alcohol intake on bone mineral density (BMD) remains unclear. This study explored the association and causality between alcohol intake and BMD.
METHODS
Based on the 2005-2020 National Health and Nutrition Examination Survey including 14,113 participants, we conducted co-variate-adjusted multilinear regression analyses to explore the association between alcohol intake levels and spine or femur BMD. To evaluate the causal association between alcohol intake frequency and bone mineral density, the inverse variance weighted approach of two-sample Mendelian randomization (MR) was used with genetic data from the Medical Research Council Integrative Epidemiology Unit (462,346 cases) for alcohol intake frequency and the Genetic Factors for Osteoporosis Consortium (28,496 cases) for lumbar spine and femur neck BMD (32,735 cases).
RESULTS
Compared with non-drinkers, total femur BMDs but not total spine BMD increased with daily alcohol intake in males (β = 3.6310 for mild drinkers, β = 4.2110 for moderate drinkers, and β = 4.2610 for heavy drinkers). By contrast, the higher total spine BMD in females was related to higher alcohol intake levels (β = 2.1510 for mild drinkers, β = 2.5910 for moderate drinkers, and β = 3.8810 for heavy drinkers). Regarding the two-sample MR results, no causal relationship was observed between alcohol intake frequency and lumbar spine BMD (odds ratio [OR] = 1.016, P = 0.789) or femur neck BMD (OR = 1.048, P = 0.333).
CONCLUSION
This study suggests a positive association between alcohol intake frequency and BMD, although the causal relationship was not significant.
未加标签
我们使用了来自 NHANES 横断面研究的 14113 名参与者的数据，表明饮酒频率与不同身体部位的骨矿物质密度之间存在正相关关系。进行了孟德尔随机化，这两个变量之间没有显著的因果关系。该研究可以为骨质疏松症患者的日常饮酒提供一些建议。
目的
饮酒对骨矿物质密度（BMD）的影响尚不清楚。本研究探讨了饮酒与 BMD 之间的关联和因果关系。
方法
基于包括 14113 名参与者的 2005-2020 年国家健康与营养调查，我们进行了协变量调整的多元线性回归分析，以探讨饮酒水平与脊柱或股骨 BMD 之间的关系。为了评估饮酒频率与骨矿物质密度之间的因果关系，使用来自医学研究理事会综合流行病学单位（462346 例）的酒精摄入频率的逆方差加权两样本孟德尔随机化（MR）方法和骨质疏松症遗传因素联盟（28496 例）用于腰椎和股骨颈 BMD（32735 例）。
结果
与不饮酒者相比，男性总股骨 BMD 而非总脊柱 BMD 随每日饮酒量增加而增加（轻度饮酒者为 3.6310，中度饮酒者为 4.2110，重度饮酒者为 4.2610）。相比之下，女性较高的总脊柱 BMD 与较高的饮酒水平相关（轻度饮酒者为 2.1510，中度饮酒者为 2.5910，重度饮酒者为 3.8810）。关于两样本 MR 结果，饮酒频率与腰椎 BMD（比值比 [OR] = 1.016，P = 0.789）或股骨颈 BMD（OR = 1.048，P = 0.333）之间没有因果关系。
结论
本研究表明饮酒频率与 BMD 之间存在正相关关系，尽管因果关系不显著。
Zotero 插件