子宫内膜异位症与冠心病之间的因果关联：来自美国国家健康与营养检查调查及孟德尔随机化分析的证据。

Causal Association Between Endometriosis and Coronary Heart Disease: Evidence from the National Health and Nutrition Examination Survey and Mendelian Randomization Analysis.

作者信息

Xu Wenting, Huang Yanxing, Ji Ping, Wang Jiayu, Yu Jinfen, Yang Li

机构信息

Department of Reproduction, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, Jiangsu, People's Republic of China.

Department of Obstetrics and Gynaecology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, Jiangsu, People's Republic of China.

出版信息

Int J Womens Health. 2024 Dec 28;16:2387-2398. doi: 10.2147/IJWH.S493708. eCollection 2024.

DOI:10.2147/IJWH.S493708

PMID:39749025

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11693947/

Abstract

OBJECTIVE

Failure to resolve inflammation is a novel feature of angiogenic-dependent diseases such as endometriosis and atherosclerosis.The correlation and causality between endometriosis and coronary heart disease is unclear. Here, we investigated the correlation and causality between endometriosis and coronary heart disease.

METHODS

The relevant data was extracted from the NHANES database (Year range: 1999-2006) and analyzed to determine the correlation between endometriosis and coronary heart disease using weighted multivariable logistic regression models. Mendelian randomization analysis was used to assess the causal relationship between endometriosis and coronary heart disease risk.

RESULTS

We evaluated the data obtained from 3943 participants and did not observe any association between endometriosis and coronary heart disease in weighted multivariable logistic regression models (Model 1, OR: 1.85, 95% CI: 0.66-5.15, P: 0.23; Model 2, OR: 0.89, 95% CI: 0.30-2.62, P: 0.82; Model 3, OR: 0.61, 95% CI: 0.19-1.95, P: 0.38). Two-sample Mendelian randomization analysis did not reveal a causal relationship between endometriosis and coronary heart disease (OR: 1.00, 95% CI: 0.94-1.07, P: 0.882).

CONCLUSION

Our findings did not indicate any association or causal relationship between endometriosis and coronary heart disease.

摘要

目的

炎症未能消退是诸如子宫内膜异位症和动脉粥样硬化等血管生成依赖性疾病的一个新特征。子宫内膜异位症与冠心病之间的相关性及因果关系尚不清楚。在此，我们研究了子宫内膜异位症与冠心病之间的相关性及因果关系。

方法

从美国国家健康与营养检查调查（NHANES）数据库（年份范围：1999 - 2006年）中提取相关数据，并使用加权多变量逻辑回归模型进行分析，以确定子宫内膜异位症与冠心病之间的相关性。采用孟德尔随机化分析来评估子宫内膜异位症与冠心病风险之间的因果关系。

结果

我们评估了从3943名参与者获得的数据，在加权多变量逻辑回归模型中未观察到子宫内膜异位症与冠心病之间存在任何关联（模型1，比值比：1.85，95%置信区间：0.66 - 5.15，P值：0.23；模型2，比值比：0.89，95%置信区间：0.30 - 2.62，P值：0.82；模型3，比值比：0.61，95%置信区间：0.19 - 1.95，P值：0.38）。两样本孟德尔随机化分析未揭示子宫内膜异位症与冠心病之间存在因果关系（比值比：1.00，95%置信区间：0.94 - 1.07，P值：0.882）。