软饮料摄入与墨西哥成年人肾小球滤过率降低的关联：RenMex 研究结果。

Association between soft drinks intake and low glomerular filtration rate in Mexican adults: Results from RenMex.

机构信息

Research Center in Policies, Population and Health, School of Medicine, National Autonomous University of Mexico (UNAM), Mexico City, Mexico.

Genomics of Bone Metabolism Laboratory, National Institute of Genomic Medicine, Mexico City, Mexico.

出版信息

Clin Nutr. 2024 Apr;43(4):1062-1069. doi: 10.1016/j.clnu.2024.03.002. Epub 2024 Mar 8.

DOI:10.1016/j.clnu.2024.03.002

PMID:38547595

Abstract

BACKGROUND & AIMS: To evaluate the association between soft drinks (SDs) consumption and estimated glomerular filtration rate (eGFR) in a Mexican adult population.

METHODS

We used data from the RenMex consortium (n = 2095) that included the Mexican Teachers Cohort Study (34-65 years), the Health Workers Cohort Study (18-90 years), and the Comitán Study (19-91 years). In this cross-sectional study, we assessed SDs consumption (cola and flavored soda) using a food frequency questionnaire (FFQ) and estimated eGFR using the CKD Epidemiology Collaboration equation. Quantile regression was used to assess the association between SDs consumption and eGFR with eGFR as a continuous variable. Multinomial logistic regression models were used for eGFR categories derived from quantile regression (mildly decreased eGFR, ≥72.9-87.9 mL/min/1.73 m and moderately decreased eGFR, <72.9 mL/min/1.73 m).

RESULTS

Mean age of study participants was 47.2 years, 67.5% were women, and 12.2% had diabetes. eGFR was <60 mL/min/1.73 m in 3.7% of study participants. Mildly decreased eGFR was present in 14.8%, and moderately decreased eGFR was present in 10.1% of study participants. Quantile regression results showed that SDs consumption was associated with lower eGFR at the 10th, 25th, 50th and 75th percentile. Based on the final adjusted multinomial model, ≥7 servings/week was positively associated with moderately decreased eGFR relative to <1 serving/week (Relative Risk Ratio = 1.95; 95% CI: 1.07-3.57).

CONCLUSION

Our results suggest that higher SDs consumption is associated with lower eGFR. Encouraging healthy dietary choices should be part of the management and prevention of CKD.

摘要

背景与目的

评估软饮料（SDs）消费与墨西哥成年人估计肾小球滤过率（eGFR）之间的关联。

方法

我们使用了 RenMex 联盟的数据（n=2095），其中包括墨西哥教师队列研究（34-65 岁）、卫生工作者队列研究（18-90 岁）和科米坦研究（19-91 岁）。在这项横断面研究中，我们使用食物频率问卷（FFQ）评估 SDs 消费（可乐和调味苏打水），并使用 CKD 流行病学合作方程估计 eGFR。使用分位数回归评估 SDs 消费与 eGFR 之间的关联，将 eGFR 作为连续变量。使用来自分位数回归的 eGFR 类别（轻度降低的 eGFR，≥72.9-87.9mL/min/1.73m 和中度降低的 eGFR，<72.9mL/min/1.73m）的多项逻辑回归模型。

结果

研究参与者的平均年龄为 47.2 岁，67.5%为女性，12.2%患有糖尿病。研究参与者中 3.7%的 eGFR<60mL/min/1.73m。14.8%存在轻度降低的 eGFR，10.1%存在中度降低的 eGFR。分位数回归结果表明，SDs 消费与第 10、25、50 和 75 百分位的 eGFR 降低相关。基于最终调整的多项模型，与每周<1 份相比，每周≥7 份与中度降低的 eGFR 呈正相关（相对风险比=1.95；95%置信区间：1.07-3.57）。