Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Shandong University, Jinan, China; Medical Integration and Practice Center, Cheeloo College of Medicine, Shandong University, Jinan, China; Jinan Key Laboratory of Diagnosis and Treatment of Major Gynecological Disease, Jinan, Shandong Province China; Gynecology Laboratory, Shandong Provincial Hospital, Jinan Shandong Province, China; Gynecology Laboratory, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan Shandong Province, China.
Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Shandong University, Jinan, China; Jinan Key Laboratory of Diagnosis and Treatment of Major Gynecological Disease, Jinan, Shandong Province China; Gynecology Laboratory, Shandong Provincial Hospital, Jinan Shandong Province, China; Gynecology Laboratory, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan Shandong Province, China.
J Trace Elem Med Biol. 2024 Jul;84:127436. doi: 10.1016/j.jtemb.2024.127436. Epub 2024 Mar 18.
This review comprehensively explores the complex role of copper homeostasis in female reproductive system diseases. As an essential trace element, copper plays a crucial role in various biological functions. Its dysregulation is increasingly recognized as a pivotal factor in the pathogenesis of gynecological disorders. We investigate how copper impacts these diseases, focusing on aspects like oxidative stress, inflammatory responses, immune function, estrogen levels, and angiogenesis. The review highlights significant changes in copper levels in diseases such as cervical, ovarian, endometrial cancer, and endometriosis, underscoring their potential roles in disease mechanisms and therapeutic exploration. The recent discovery of 'cuproptosis,' a novel cell death mechanism induced by copper ions, offers a fresh molecular perspective in understanding these diseases. The review also examines genes associated with cuproptosis, particularly those related to drug resistance, suggesting new strategies to enhance traditional therapy effectiveness. Additionally, we critically evaluate current therapeutic approaches targeting copper homeostasis, including copper ionophores, chelators, and nanoparticles, emphasizing their emerging potential in gynecological disease treatment. This article aims to provide a comprehensive overview of copper's role in female reproductive health, setting the stage for future research to elucidate its mechanisms and develop targeted therapeutic strategies.
这篇综述全面探讨了铜稳态在女性生殖系统疾病中的复杂作用。作为一种必需的微量元素，铜在各种生物功能中起着关键作用。其失调越来越被认为是妇科疾病发病机制中的关键因素。我们研究了铜如何影响这些疾病，重点关注氧化应激、炎症反应、免疫功能、雌激素水平和血管生成等方面。该综述强调了铜水平在宫颈癌、卵巢癌、子宫内膜癌和子宫内膜异位症等疾病中的显著变化，突出了其在疾病机制和治疗探索中的潜在作用。最近发现的“铜死亡”，即铜离子诱导的一种新型细胞死亡机制，为理解这些疾病提供了一个新的分子视角。该综述还研究了与铜死亡相关的基因，特别是与耐药性相关的基因，提示了增强传统治疗效果的新策略。此外，我们还批判性地评估了目前针对铜稳态的治疗方法，包括铜载体、螯合剂和纳米颗粒，强调了它们在妇科疾病治疗中的新兴潜力。本文旨在全面概述铜在女性生殖健康中的作用，为阐明其机制和开发靶向治疗策略奠定基础。
