Zhang Limei, Xie Aihui, Ma Jingxian, Liu Huilin, Zeng Changchun
Department of Gastroenterology, Shenzhen Longhua District Central Hospital, Shenzhen 518110, China.
Institute for Brain Research and Rehabilitation, South China Normal University, Guangzhou 510631, China.
Biochim Biophys Acta Rev Cancer. 2024 Nov;1879(6):189180. doi: 10.1016/j.bbcan.2024.189180. Epub 2024 Sep 12.
Copper, a vital micronutrient, performs essential functions in numerous biological settings. Its disrupted metabolism is implicated in both the initiation of tumors and therapeutic interventions for cancer, underscoring the critical necessity of preserving copper homeostasis. Cuproptosis, a regulated cell death (RCD) modulated by copper, is activated in response to elevated copper concentrations, prompting an investigation into its implication in oncogenesis. Within this review, an exploration is conducted into copper dynamics and homeostasis maintenance within cells. Furthermore, it delves into the mechanisms underlying cuproptosis and its interplay with signaling pathways implicated in cancer. The potential synergy between cuproptosis and ferroptosis and its impact on tumor immunomodulation is discussed. Additionally, promising avenues for addressing cuproptosis in cancer involve assessing the utility of copper chelators and ionophores. By addressing pressing questions surrounding cuproptosis and outlining its pivotal role in cancer pathogenesis and treatment, this review propounds targeting cuproptosis as a promising frontier in antitumor therapy, potentially revolutionizing cancer treatment strategies.
铜作为一种至关重要的微量营养素，在众多生物环境中发挥着重要作用。其代谢紊乱与肿瘤的发生以及癌症的治疗干预均有关联，这凸显了维持铜稳态的关键必要性。铜死亡是一种由铜调节的程序性细胞死亡（RCD），在铜浓度升高时被激活，这促使人们对其在肿瘤发生中的作用展开研究。在本综述中，我们对细胞内的铜动态和稳态维持进行了探索。此外，还深入研究了铜死亡的潜在机制及其与癌症相关信号通路的相互作用。探讨了铜死亡与铁死亡之间的潜在协同作用及其对肿瘤免疫调节的影响。此外，解决癌症中铜死亡问题的有前景的途径包括评估铜螯合剂和离子载体的效用。通过解决围绕铜死亡的紧迫问题并概述其在癌症发病机制和治疗中的关键作用，本综述提出将靶向铜死亡作为抗肿瘤治疗的一个有前景的前沿领域，可能会彻底改变癌症治疗策略。
