Department of Epidemiology and Biostatistics, School of Public Health of Jilin University, Changchun 130021, China.
Department of Epidemiology and Biostatistics, School of Public Health of Jilin University, Changchun 130021, China.
Sci Total Environ. 2024 Jun 1;927:172008. doi: 10.1016/j.scitotenv.2024.172008. Epub 2024 Mar 26.
Little has been known on the effect of chronic glyphosate exposure on osteoarthritis (OA). The aim of this study was to investigate the association between glyphosate exposure and OA and to further investigate the different moderating effects of leisure time physical activity (LTPA) and body mass index (BMI) types on the association between glyphosate exposure and OA.
Cross-sectional data from 2540 participants in the 2015-2018 National Health and Nutrition Examination Survey (NHANES) were used to explore the association between glyphosate exposure and OA. Multivariate logistic regression models and restricted cubic spline models were used to investigate the association between glyphosate exposure and OA, and further analyses were conducted to determine the association between glyphosate exposure and OA under different LTPA and BMI types.
Of the 2540 participants, 346 had OA. Participants with the highest glyphosate concentration (Q4) had a higher incidence of OA compared to participants with the lowest glyphosate concentration (Q1) (OR, 1.88; 95 % confidence interval [CI]: 1.13, 3.13), there was no nonlinear association between glyphosate and OA (non-linear P = 0.343). In the no LTPA group, glyphosate concentration in the Q4 group was correlated with OA (OR, 2.65; 95%CI: 1.27, 5.51). In the obese group, glyphosate concentration in the Q4 group was correlated with OA (OR, 2.74; 95 % CI: 1.48, 5.07). Among people with high BMI and inactive in LTPA, glyphosate concentrations in Q4 were associated with OA (OR, 2.19; 95 % CI: 1.07, 4.48).
Glyphosate is associated with OA odd, and physical activity and moderate weight loss can mitigate this association to some degree. This study provides a scientific basis for rational prevention of OA by regulation of LTPA and BMI under glyphosate exposure.
关于慢性草甘膦暴露对骨关节炎（OA）的影响，人们知之甚少。本研究旨在探讨草甘膦暴露与 OA 之间的关联，并进一步探讨休闲时间体力活动（LTPA）和体重指数（BMI）类型对草甘膦暴露与 OA 之间关联的不同调节作用。
使用 2015-2018 年全国健康与营养调查（NHANES）中 2540 名参与者的横断面数据，探讨草甘膦暴露与 OA 之间的关系。采用多变量逻辑回归模型和限制立方样条模型，探讨草甘膦暴露与 OA 之间的关系，并进一步分析不同 LTPA 和 BMI 类型下草甘膦暴露与 OA 之间的关系。
在 2540 名参与者中，有 346 人患有 OA。与草甘膦浓度最低的 Q1 组相比，草甘膦浓度最高的 Q4 组 OA 发生率更高（OR，1.88；95%置信区间[CI]：1.13，3.13），草甘膦与 OA 之间不存在非线性关系（非线性 P=0.343）。在无 LTPA 组中，Q4 组草甘膦浓度与 OA 相关（OR，2.65；95%CI：1.27，5.51）。在肥胖组中，Q4 组草甘膦浓度与 OA 相关（OR，2.74；95%CI：1.48，5.07）。在 BMI 较高且 LTPA 不活跃的人群中，Q4 组的草甘膦浓度与 OA 相关（OR，2.19；95%CI：1.07，4.48）。
草甘膦与 OA 呈正相关，体力活动和适度减肥可以在一定程度上减轻这种相关性。本研究为通过调节草甘膦暴露下的 LTPA 和 BMI 进行合理预防 OA 提供了科学依据。
