Riyahi Javad, Taslimi Zahra, Gelfo Francesca, Petrosini Laura, Haghparast Abbas
Department of Cognitive and Behavioral Science and Technology in Sport, Faculty of Sport Sciences and Health, Shahid Beheshti University, Tehran, Iran.
Behavioral Disorders and Substance Abuse Research Center, Hamadan University of Medical Sciences, Hamadan, Iran; Fertility and Infertility Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Neurosci Biobehav Rev. 2024 May;160:105644. doi: 10.1016/j.neubiorev.2024.105644. Epub 2024 Mar 26.
Recent evidence reported that parental-derived phenotypes can be passed on to the next generations. Within the inheritance of epigenetic characteristics allowing the transmission of information related to the ancestral environment to the offspring, the specific case of the trans-generational effects of parental drug addiction has been extensively studied. Drug addiction is a chronic disorder resulting from complex interactions among environmental, genetic, and drug-related factors. Repeated exposures to drugs induce epigenetic changes in the reward circuitry that in turn mediate enduring changes in brain function. Addictive drugs can exert their effects trans-generally and influence the offspring of addicted parents. Although there is growing evidence that shows a wide range of behavioral, physiological, and molecular phenotypes in inter-, multi-, and trans-generational studies, transmitted phenotypes often vary widely even within similar protocols. Given the breadth of literature findings, in the present review, we restricted our investigation to learning and memory performances, as examples of the offspring's complex behavioral outcomes following parental exposure to drugs of abuse, including morphine, cocaine, cannabinoids, nicotine, heroin, and alcohol.
最近有证据表明，源自父母的表型可以传递给下一代。在表观遗传特征的遗传中，允许与祖先环境相关的信息传递给后代，父母药物成瘾的跨代效应这一特定情况已得到广泛研究。药物成瘾是一种慢性疾病，由环境、遗传和药物相关因素之间的复杂相互作用导致。反复接触药物会在奖赏回路中诱导表观遗传变化，进而介导大脑功能的持久改变。成瘾药物可产生跨代效应，并影响成瘾父母的后代。尽管越来越多的证据表明，在代间、多代和跨代研究中存在广泛的行为、生理和分子表型，但即使在相似的实验方案中，传递的表型也往往差异很大。鉴于文献研究结果的广度，在本综述中，我们将研究局限于学习和记忆表现，作为父母接触滥用药物（包括吗啡、可卡因、大麻素、尼古丁、海洛因和酒精）后后代复杂行为结果的示例。
