Sadat-Shirazi Mitra-Sadat, Sadeghi-Adl Mahsa, Akbarabadi Ardeshir, Ashabi Ghorbangol, Mokri Azarakhsh, Zarrindast Mohammad-Reza
Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran.
Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
CNS Neurol Disord Drug Targets. 2023;22(4):512-538. doi: 10.2174/1871527321666220429122819.
Drug addiction is a chronic relapsing disorder that makes it a global problem. Genetics and environmental factors are the two most important factors that make someone vulnerable to drug addiction. Investigations in the past decade highlighted the role of epigenetics in the inter/transgenerational inheritance of drug addiction. A growing body of evidence showed that parental (paternal, maternal, and biparental) drug exposure before conception changes the phenotype of the offspring, which is correlated with neurochemical and neurostructural changes in the brain. The current paper reviews the effects of parental (maternal, paternal, and biparental) exposure to drugs of abuse (opioids, cocaine, nicotine, alcohol, and cannabis) before gestation in animal models.
药物成瘾是一种慢性复发性疾病，使其成为一个全球性问题。遗传因素和环境因素是使某人易患药物成瘾的两个最重要因素。过去十年的研究突出了表观遗传学在药物成瘾的代际/跨代遗传中的作用。越来越多的证据表明，受孕前父母（父亲、母亲和双亲）接触药物会改变后代的表型，这与大脑中的神经化学和神经结构变化相关。本文综述了动物模型中妊娠前父母（母亲、父亲和双亲）接触滥用药物（阿片类药物、可卡因、尼古丁、酒精和大麻）的影响。
