Yohn Nicole L, Bartolomei Marisa S, Blendy Julie A
Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Prog Biophys Mol Biol. 2015 Jul;118(1-2):21-33. doi: 10.1016/j.pbiomolbio.2015.03.002. Epub 2015 Apr 1.
Familial inheritance of drug abuse is composed of both genetic and environmental factors. Additionally, epigenetic transgenerational inheritance may provide a means by which parental drug use can influence several generations of offspring. Recent evidence suggests that parental drug exposure produces behavioral, biochemical, and neuroanatomical changes in future generations. The focus of this review is to discuss these multigenerational and transgenerational phenotypes in the offspring of animals exposed to drugs of abuse. Specifically, changes found following the administration of alcohol, opioids, cocaine, marijuana, and nicotine will be discussed. In addition, epigenetic modifications to the genome following administration of these drugs will be detailed as well as their potential for transmission to the next generation.
药物滥用的家族遗传由遗传和环境因素共同构成。此外，表观遗传的跨代遗传可能提供一种方式，通过它父母的药物使用能够影响几代后代。最近的证据表明，父母的药物暴露会在后代中产生行为、生化和神经解剖学上的变化。本综述的重点是讨论暴露于滥用药物的动物后代中的这些多代和跨代表型。具体而言，将讨论在给予酒精、阿片类药物、可卡因、大麻和尼古丁后发现的变化。此外，还将详细介绍给予这些药物后基因组的表观遗传修饰及其向下一代传递的可能性。
