乳酸在肿瘤微环境中的新作用及其临床意义。
The emerging role of lactate in tumor microenvironment and its clinical relevance.
作者信息
Chen Sihan, Xu Yining, Zhuo Wei, Zhang Lu
机构信息
Department of Cell Biology and Department of Colorectal Surgery and Oncology, Center for Medical Research and Innovation in Digestive System Tumors, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Cancer Center, Zhejiang University, Hangzhou, China; Institute of Gastroenterology, Zhejiang University, Hangzhou, China.
Department of Cell Biology and Department of Colorectal Surgery and Oncology, Center for Medical Research and Innovation in Digestive System Tumors, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Cancer Center, Zhejiang University, Hangzhou, China; Institute of Gastroenterology, Zhejiang University, Hangzhou, China.
出版信息
Cancer Lett. 2024 May 28;590:216837. doi: 10.1016/j.canlet.2024.216837. Epub 2024 Mar 26.
In recent years, the significant impact of lactate in the tumor microenvironment has been greatly documented. Acting not only as an energy substance in tumor metabolism, lactate is also an imperative signaling molecule. It plays key roles in metabolic remodeling, protein lactylation, immunosuppression, drug resistance, epigenetics and tumor metastasis, which has a tight relation with cancer patients' poor prognosis. This review illustrates the roles lactate plays in different aspects of tumor progression and drug resistance. From the comprehensive effects that lactate has on tumor metabolism and tumor immunity, the therapeutic targets related to it are expected to bring new hope for cancer therapy.
近年来，乳酸在肿瘤微环境中的重大影响已得到大量记载。乳酸不仅作为肿瘤代谢中的一种能量物质，还是一种必不可少的信号分子。它在代谢重塑、蛋白质乳酸化、免疫抑制、耐药性、表观遗传学和肿瘤转移中发挥关键作用，这与癌症患者的不良预后密切相关。本综述阐述了乳酸在肿瘤进展和耐药性不同方面所起的作用。从乳酸对肿瘤代谢和肿瘤免疫的综合影响来看，与之相关的治疗靶点有望为癌症治疗带来新希望。
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