脂肪间充质干细胞外泌体促进伤口血管生成机制的研究进展
[Research advances on the mechanism of extracellular vesicles of adipose-derived mesenchymal stem cells in promoting wound angiogenesis].
作者信息
Ju Y K, Fang B R
机构信息
Department of Plastic and Aesthetic (Burn) Surgery, the Second Xiangya Hospital, Central South University, Changsha 410011, China.
出版信息
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2023 Jan 20;39(1):85-90. doi: 10.3760/cma.j.cn501225-20220322-00080.
Abstract
Wound healing involves complex pathophysiological mechanism, among which angiogenesis is considered as one of the key steps in wound healing, and promoting wound angiogenesis can accelerate wound healing. In recent years, mesenchymal stem cell-derived extracellular vesicles have been proven to produce equivalent effects of wound healing promotion comparable to stem cell therapy, with the advantages of low antigenicity and high biocompatibility. The specific mechanism by which extracellular vesicles facilitate wound healing is still not fully understood and is thought to involve all stages of wound healing. This article focuses on the possible mechanism of extracellular vesicles of adipose-derived mesenchymal stem cells in promoting wound angiogenesis, so as to provide ideas for further study on the mechanism of extracellular vesicles to promote wound healing.
摘要
伤口愈合涉及复杂的病理生理机制，其中血管生成被认为是伤口愈合的关键步骤之一，促进伤口血管生成可加速伤口愈合。近年来，间充质干细胞衍生的细胞外囊泡已被证明具有与干细胞疗法相当的促进伤口愈合的效果，具有低抗原性和高生物相容性的优点。细胞外囊泡促进伤口愈合的具体机制仍未完全了解，被认为涉及伤口愈合的各个阶段。本文重点探讨脂肪来源间充质干细胞的细胞外囊泡促进伤口血管生成的可能机制，为进一步研究细胞外囊泡促进伤口愈合的机制提供思路。
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