Department of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Hubei Provincial Clinical Research Center for Parkinson's Disease, Central Laboratory, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang 44100, China; Hubei Key Laboratory of Precision Radiation Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Cytokine Growth Factor Rev. 2024 Jun;77:67-75. doi: 10.1016/j.cytogfr.2024.03.003. Epub 2024 Mar 19.
Macrophage migration inhibitory factor (MIF) is a cytokine in the immune system, participated in both innate and adaptive immune responses. Except from immune cells, MIF is also secreted by a variety of non-immune cells, including hematopoietic cells, endothelial cells (ECs), and neurons. MIF plays a crucial role in various diseases, such as sepsis, rheumatoid arthritis, acute kidney injury, and neurodegenerative diseases. The role of MIF in the neuropathogenesis of cognitive impairment disorders is emphasized, as it recruits multiple inflammatory mediators, leading to activating microglia or astrocyte-derived neuroinflammation. Furthermore, it contributes to the cell death of neurons and ECs with the binding of apoptosis-inducing factor (AIF) through parthanatos-associated apoptosis-inducing factor nuclease (PAAN) / MIF pathway. This review comprehensively delves into the relationship between MIF and the neuropathogenesis of cognitive impairment disorders, providing a series of emerging MIF-targeted pharmaceuticals as potential treatments for cognitive impairment disorders.
巨噬细胞移动抑制因子（MIF）是免疫系统中的一种细胞因子，参与固有和适应性免疫反应。除免疫细胞外，MIF 还由各种非免疫细胞分泌，包括造血细胞、内皮细胞（EC）和神经元。MIF 在多种疾病中发挥着关键作用，如败血症、类风湿关节炎、急性肾损伤和神经退行性疾病。MIF 在认知障碍疾病的神经发病机制中的作用得到了强调，因为它招募了多种炎症介质，导致激活小胶质细胞或星形胶质细胞源性神经炎症。此外，它通过与凋亡诱导因子（AIF）结合的 parthanatos 相关凋亡诱导因子核酸酶（PAAN）/MIF 途径导致神经元和 EC 细胞死亡。本综述全面探讨了 MIF 与认知障碍疾病的神经发病机制之间的关系，并提供了一系列新兴的 MIF 靶向药物作为认知障碍疾病的潜在治疗方法。
