Chen Ying, Pang Yuanxiang, Wan Hongbing, Zhou Xinyi, Wan Mingli, Li Shengshuo, Liu Xuelian
State Key Laboratory of Forage Microbiology Engineering, Beijing Da Bei Nong Group, Beijing, 100194, China.
Biometals. 2024 Aug;37(4):1023-1035. doi: 10.1007/s10534-024-00592-3. Epub 2024 Mar 28.
Iron deficiency anemia (IDA) is one of the most serious forms of malnutrition. Wild type strains of Saccharomyces cerevisiae have higher tolerance to inorganic iron and higher iron conversion and accumulation capacity. The aim of this study was to investigate the effect of S. cerevisiae enriched iron as a potential organic iron supplement on mice with iron deficiency anemia. 60 male Kunming mice (KM mice, with strong adaptability and high reproduction rate, it can be widely used in pharmacology, toxicology, microbiology and other research) were randomly divided into normal control group and iron deficiency diet model group to establish IDA model. After the model was established, IDA mice were randomly divided into 5 groups: normal control group, IDA group, organic iron group (ferrous glycinate), inorganic iron group (ferrous sulfate) and S. cerevisiae enriched iron group. Mice in the experimental group were given different kinds of iron by intragastric administration once a day for 4w. The results showed that S. cerevisiae enriched iron had an effective recovery function, and the body weight and hematological parameters of IDA mice returned to normal levels. The activities of superoxide dismutase, glutathione peroxidase and total antioxidant capacity in serum were increased. In addition, the strain no. F8, able to grow in an iron-rich environment, was more effective in alleviating IDA and improving organ indices with fewer side effects compared to ferrous glycinate and ferrous sulfate groups. This study suggests that the iron-rich strain no. F8 may play an important role in improving IDA mice and may be developed as a new iron supplement.
缺铁性贫血（IDA）是最严重的营养不良形式之一。酿酒酵母野生型菌株对无机铁具有较高的耐受性以及较高的铁转化和积累能力。本研究旨在探讨富含铁的酿酒酵母作为一种潜在的有机铁补充剂对缺铁性贫血小鼠的影响。60只雄性昆明小鼠（KM小鼠，适应性强、繁殖率高，可广泛用于药理学、毒理学、微生物学等研究）被随机分为正常对照组和缺铁饮食模型组以建立IDA模型。模型建立后，将缺铁性贫血小鼠随机分为5组：正常对照组、缺铁性贫血组、有机铁组（甘氨酸亚铁）、无机铁组（硫酸亚铁）和富含铁的酿酒酵母组。实验组小鼠每天经胃内给药一次不同种类的铁，持续4周。结果表明，富含铁的酿酒酵母具有有效的恢复功能，缺铁性贫血小鼠的体重和血液学参数恢复到正常水平。血清中超氧化物歧化酶、谷胱甘肽过氧化物酶的活性以及总抗氧化能力均有所提高。此外，能够在富铁环境中生长的F8菌株在缓解缺铁性贫血和改善器官指数方面比甘氨酸亚铁和硫酸亚铁组更有效，且副作用更少。本研究表明，富含铁的F8菌株可能在改善缺铁性贫血小鼠方面发挥重要作用，并可能被开发为一种新型铁补充剂。
