早期铁缺乏对大脑和行为的长期影响。
Long-term brain and behavioral consequences of early iron deficiency.
机构信息
Center for Neurobehavioral Development, University of Minnesota School of Medicine and College of Education and Human Development, Minneapolis, Minnesota 55455, USA.
出版信息
Nutr Rev. 2011 Nov;69 Suppl 1(Suppl 1):S43-8. doi: 10.1111/j.1753-4887.2011.00432.x.
Abstract
Early iron deficiency not only affects brain and behavioral function during the period of iron deficiency, it persists long after treatment. The mechanisms include long-term alterations in dopamine metabolism, myelination, and hippocampal structure and function. Recent studies have demonstrated long-term genomic changes, which suggests the regulation of brain function is fundamentally altered.
摘要
早期缺铁不仅会影响缺铁期间的大脑和行为功能，而且在治疗后还会持续很长时间。其机制包括多巴胺代谢、髓鞘形成以及海马结构和功能的长期改变。最近的研究表明存在长期的基因组变化，这提示大脑功能的调节已发生根本改变。
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