• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

通过鼻腔共递送甘丙肽受体 2 (GALR2) 和神经肽 Y 受体 1 (NPY1R) 激动剂增强神经发生和认知：认知功能障碍的潜在药物治疗策略。

Enhancement of neurogenesis and cognition through intranasal co-delivery of galanin receptor 2 (GALR2) and neuropeptide Y receptor 1 (NPY1R) agonists: a potential pharmacological strategy for cognitive dysfunctions.

机构信息

NeuronLab. Departamento Fisiología Humana, Histología Humana, Anatomía Patológica y Educación Física y Deportiva, Facultad de Medicina, Universidad de Malaga, 29071, Malaga, Spain.

Instituto de Investigación Biomédica de Málaga-IBIMA-Plataforma Bionand, Universidad de Malaga, 29071, Malaga, Spain.

出版信息

Behav Brain Funct. 2024 Mar 28;20(1):6. doi: 10.1186/s12993-024-00230-5.

DOI:10.1186/s12993-024-00230-5
PMID:38549164
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10976774/
Abstract

BACKGROUND

Spatial memory deficits and reduced neuronal survival contribute to cognitive decline seen in the aging process. Current treatments are limited, emphasizing the need for innovative therapeutic strategies. This research explored the combined effects of intranasally co-administered galanin receptor 2 (GALR2) and neuropeptide Y1 receptor (NPY1R) agonists, recognized for their neural benefits, on spatial memory, neuronal survival, and differentiation in adult rats. After intranasal co-delivery of the GALR2 agonist M1145 and a NPY1R agonist to adult rats, spatial memory was tested with the object-in-place task 3 weeks later. We examined neuronal survival and differentiation by assessing BrdU-IR profiles and doublecortin (DCX) labeled cells, respectively. We also used the GALR2 antagonist M871 to confirm GALR2's crucial role in promoting cell growth.

RESULTS

Co-administration improved spatial memory and increased the survival rate of mature neurons. The positive effect of GALR2 in cell proliferation was confirmed by the nullifying effects of its antagonist. The treatment boosted DCX-labeled newborn neurons and altered dendritic morphology, increasing cells with mature dendrites.

CONCLUSIONS

Our results show that intranasal co-delivery of GALR2 and NPY1R agonists improves spatial memory, boosts neuronal survival, and influences neuronal differentiation in adult rats. The significant role of GALR2 is emphasized, suggesting new potential therapeutic strategies for cognitive decline.

摘要

背景

空间记忆缺陷和神经元存活减少导致衰老过程中认知能力下降。目前的治疗方法有限，这强调了需要创新的治疗策略。本研究探讨了经鼻腔共给予甘丙肽受体 2（GALR2）和神经肽 Y1 受体（NPY1R）激动剂的联合效应，这些激动剂因其对神经的益处而被认可，对成年大鼠的空间记忆、神经元存活和分化的影响。在成年大鼠经鼻腔共给予 GALR2 激动剂 M1145 和 NPY1R 激动剂后，3 周后用位置物体识别任务测试空间记忆。我们通过评估 BrdU-IR 图谱和双皮质素（DCX）标记细胞分别检查神经元存活和分化。我们还使用 GALR2 拮抗剂 M871 来确认 GALR2 在促进细胞生长中的关键作用。

结果

共给药改善了空间记忆并提高了成熟神经元的存活率。其拮抗剂的中和作用证实了 GALR2 在细胞增殖中的积极作用。该治疗方法增加了 DCX 标记的新生神经元，并改变了树突形态，增加了具有成熟树突的细胞。

结论

我们的研究结果表明，经鼻腔共给予 GALR2 和 NPY1R 激动剂可改善成年大鼠的空间记忆，促进神经元存活，并影响神经元分化。强调了 GALR2 的重要作用，为认知能力下降提供了新的潜在治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10b6/10976774/2b35c83b4204/12993_2024_230_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10b6/10976774/37cd8ea3d2c0/12993_2024_230_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10b6/10976774/f6138aae50ce/12993_2024_230_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10b6/10976774/70c9a8a5515c/12993_2024_230_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10b6/10976774/2b35c83b4204/12993_2024_230_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10b6/10976774/37cd8ea3d2c0/12993_2024_230_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10b6/10976774/f6138aae50ce/12993_2024_230_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10b6/10976774/70c9a8a5515c/12993_2024_230_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10b6/10976774/2b35c83b4204/12993_2024_230_Fig4_HTML.jpg

相似文献

1
Enhancement of neurogenesis and cognition through intranasal co-delivery of galanin receptor 2 (GALR2) and neuropeptide Y receptor 1 (NPY1R) agonists: a potential pharmacological strategy for cognitive dysfunctions.通过鼻腔共递送甘丙肽受体 2 (GALR2) 和神经肽 Y 受体 1 (NPY1R) 激动剂增强神经发生和认知：认知功能障碍的潜在药物治疗策略。
Behav Brain Funct. 2024 Mar 28;20(1):6. doi: 10.1186/s12993-024-00230-5.
2
Long-term enhancements in antidepressant efficacy and neurogenesis: Effects of intranasal co-administration of neuropeptide Y 1 receptor (NPY1R) and galanin receptor 2 (GALR2) agonists in the ventral hippocampus.长期增强抗抑郁疗效和神经发生：鼻内共给予神经肽 Y1 受体（NPY1R）和甘丙肽受体 2（GALR2）激动剂对腹侧海马的影响。
FASEB J. 2024 Apr 15;38(7):e23595. doi: 10.1096/fj.202400087R.
3
Enhanced neuronal survival and BDNF elevation via long-term co-activation of galanin 2 (GALR2) and neuropeptide Y1 receptors (NPY1R): potential therapeutic targets for major depressive disorder.通过长效共激活甘丙肽 2（GALR2）和神经肽 Y1 受体（NPY1R）增强神经元存活和 BDNF 水平：治疗重度抑郁症的潜在靶点。
Expert Opin Ther Targets. 2024 Apr;28(4):295-308. doi: 10.1080/14728222.2024.2342517. Epub 2024 Apr 21.
4
Neuropeptide Y receptor 1 and galanin receptor 2 (NPY1R-GALR2) interactions in the dentate gyrus and their relevance for neurogenesis and cognition.齿状回中神经肽Y受体1与甘丙肽受体2（NPY1R - GALR2）的相互作用及其与神经发生和认知的相关性。
Front Cell Neurosci. 2024 Feb 14;18:1323986. doi: 10.3389/fncel.2024.1323986. eCollection 2024.
5
Intranasal Delivery of Galanin 2 and Neuropeptide Y1 Agonists Enhanced Spatial Memory Performance and Neuronal Precursor Cells Proliferation in the Dorsal Hippocampus in Rats.鼻内给予甘丙肽2和神经肽Y1激动剂可增强大鼠背侧海马体的空间记忆能力并促进神经元前体细胞增殖。
Front Pharmacol. 2022 Feb 14;13:820210. doi: 10.3389/fphar.2022.820210. eCollection 2022.
6
GALR2 and Y1R agonists intranasal infusion enhanced adult ventral hippocampal neurogenesis and antidepressant-like effects involving BDNF actions.GALR2 和 Y1R 激动剂经鼻内输注可增强成年海马腹侧神经发生和抗抑郁样作用，涉及 BDNF 作用。
J Cell Physiol. 2023 Feb;238(2):459-474. doi: 10.1002/jcp.30944. Epub 2023 Jan 4.
7
Galanin and neuropeptide Y interactions elicit antidepressant activity linked to neuronal precursor cells of the dentate gyrus in the ventral hippocampus.甘丙肽与神经肽Y的相互作用引发了与腹侧海马齿状回神经元前体细胞相关的抗抑郁活性。
J Cell Physiol. 2021 May;236(5):3565-3578. doi: 10.1002/jcp.30092. Epub 2020 Oct 12.
8
Enhancing Cognitive Functions and Neuronal Growth through NPY1R Agonist and Ketamine Co-Administration: Evidence for NPY1R-TrkB Heteroreceptor Complexes in Rats.通过 NPY1R 激动剂和氯胺酮联合给药增强认知功能和神经元生长：大鼠中 NPY1R-TrkB 异源受体复合物的证据。
Cells. 2024 Apr 12;13(8):669. doi: 10.3390/cells13080669.
9
GalR3 mediates galanin proliferative effects on postnatal hippocampal precursors.GalR3介导甘丙肽对出生后海马前体细胞的增殖作用。
Neuropeptides. 2017 Jun;63:14-17. doi: 10.1016/j.npep.2017.04.002. Epub 2017 Apr 5.
10
Elevated galanin receptor type 2 primarily contributes to mechanical hypersensitivity after median nerve injury.神经损伤后甘丙肽受体 2 亚型的上调主要导致机械性痛觉过敏。
PLoS One. 2018 Jun 21;13(6):e0199512. doi: 10.1371/journal.pone.0199512. eCollection 2018.

引用本文的文献

1
Integration of phytochemical profiling and computational approaches to evaluate the neuroprotective potential of in Alzheimer's disease.整合植物化学图谱分析和计算方法以评估[具体物质]在阿尔茨海默病中的神经保护潜力。 （原文中“of”后面缺失具体内容）
Biotechnol Rep (Amst). 2025 Feb 8;45:e00881. doi: 10.1016/j.btre.2025.e00881. eCollection 2025 Mar.

本文引用的文献

1
Decreased medial prefrontal cortex activity related to impaired novel object preference task performance following GALR2 and Y1R agonists intranasal infusion.鼻内注射GALR2和Y1R激动剂后，内侧前额叶皮质活动减少与新奇物体偏好任务表现受损有关。
Biomed Pharmacother. 2023 May;161:114433. doi: 10.1016/j.biopha.2023.114433. Epub 2023 Feb 26.
2
GALR2 and Y1R agonists intranasal infusion enhanced adult ventral hippocampal neurogenesis and antidepressant-like effects involving BDNF actions.GALR2 和 Y1R 激动剂经鼻内输注可增强成年海马腹侧神经发生和抗抑郁样作用，涉及 BDNF 作用。
J Cell Physiol. 2023 Feb;238(2):459-474. doi: 10.1002/jcp.30944. Epub 2023 Jan 4.
3
Intranasal Peptide Therapeutics: A Promising Avenue for Overcoming the Challenges of Traditional CNS Drug Development.
鼻腔肽治疗学：克服传统中枢神经系统药物开发挑战的有前途途径。
Cells. 2022 Nov 16;11(22):3629. doi: 10.3390/cells11223629.
4
Age-related loss of recognition memory and its correlation with hippocampal and perirhinal cortex changes in female Sprague Dawley rats.年龄相关性识别记忆丧失及其与雌性 Sprague Dawley 大鼠海马和边缘皮层变化的相关性。
Behav Brain Res. 2022 Oct 28;435:114026. doi: 10.1016/j.bbr.2022.114026. Epub 2022 Aug 5.
5
Galanin and Neuropeptide Y Interaction Enhances Proliferation of Granule Precursor Cells and Expression of Neuroprotective Factors in the Rat Hippocampus with Consequent Augmented Spatial Memory.甘丙肽与神经肽Y的相互作用增强大鼠海马颗粒前体细胞的增殖及神经保护因子的表达，从而增强空间记忆。
Biomedicines. 2022 Jun 1;10(6):1297. doi: 10.3390/biomedicines10061297.
6
Memory Enhancement with Kynurenic Acid and Its Mechanisms in Neurotransmission.犬尿喹啉酸对记忆的增强作用及其在神经传递中的机制
Biomedicines. 2022 Apr 5;10(4):849. doi: 10.3390/biomedicines10040849.
7
Response to Comment on "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis".对《神经退行性疾病对人类成年海马神经发生的影响》评论的回应
Science. 2022 Apr 15;376(6590):eabo0920. doi: 10.1126/science.abo0920.
8
Intranasal Delivery of Galanin 2 and Neuropeptide Y1 Agonists Enhanced Spatial Memory Performance and Neuronal Precursor Cells Proliferation in the Dorsal Hippocampus in Rats.鼻内给予甘丙肽2和神经肽Y1激动剂可增强大鼠背侧海马体的空间记忆能力并促进神经元前体细胞增殖。
Front Pharmacol. 2022 Feb 14;13:820210. doi: 10.3389/fphar.2022.820210. eCollection 2022.
9
The cognitive and psychiatric subacute impairment in severe Covid-19.严重 COVID-19 中的认知和精神亚急性损伤。
Sci Rep. 2022 Mar 3;12(1):3563. doi: 10.1038/s41598-022-07559-9.
10
Exploring the role of neuropeptides in depression and anxiety.探索神经肽在抑郁和焦虑中的作用。
Prog Neuropsychopharmacol Biol Psychiatry. 2022 Mar 2;114:110478. doi: 10.1016/j.pnpbp.2021.110478. Epub 2021 Nov 18.