Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.
Kids GI Kare, Cypress, TX, USA.
Pediatr Dev Pathol. 2024 May-Jun;27(3):235-240. doi: 10.1177/10935266241238625. Epub 2024 Mar 28.
We analyzed upper endoscopic and histological findings in 3 cohorts of children undergoing upper gastrointestinal endoscopy over a 10-year period. Five hundred seventy-nine patients were identified, with 244 (42%), 199 (35%), and 136 (23%) in the 2011, 2015, and 2019 cohorts, respectively. The most common symptoms and signs were abdominal pain, vomiting, failure to thrive, and diarrhea.
The number of patients who had histological evidence of chronic gastritis increased from 2011 (n = 70, 29%) to 2015 (n = 106, 53%) and 2019 (n = 92, 68%; < .001). The prevalence of "normal" endoscopic gastric findings was higher in controls (n = 247, 90%) compared to cases (n = 201, 76%; < .001). There was a small but statistically significant difference in endoscopic esophageal grading ( = .008) over time, with lower grades being more prevalent in 2011 compared to 2015 ( = .026) and 2019 ( = .001). Crude comparisons of the predictors (sex, weight percentile, payor type, month of endoscopy, symptom duration, PPI exposure, and endoscopic stomach findings) yielded no difference between cases and controls.
There has been a significant rise in the prevalence of mild chronic gastritis or non-specific gastritis over the last decade in our population.
我们分析了在过去 10 年中进行上消化道内镜检查的 3 组儿童的上内窥镜和组织学发现。确定了 579 例患者，其中 2011 年、2015 年和 2019 年分别有 244 例（42%）、199 例（35%）和 136 例（23%）。最常见的症状和体征是腹痛、呕吐、生长不良和腹泻。
有组织学证据表明患有慢性胃炎的患者人数从 2011 年（n=70，29%）增加到 2015 年（n=106，53%）和 2019 年（n=92，68%；<.001）。对照组（n=247，90%）的内镜胃发现正常比例明显高于病例组（n=201，76%；<.001）。内镜食管分级随时间略有差异（P=.008），2011 年的分级较低，与 2015 年（P=.026）和 2019 年（P=.001）相比。病例组和对照组之间对预测因素（性别、体重百分位、支付类型、内镜检查月份、症状持续时间、PPI 暴露和内镜胃发现）进行的粗略比较没有差异。
在过去十年中，我们人群中轻度慢性胃炎或非特异性胃炎的患病率显著上升。
