Obayo Siraji, Muzoora Conrad, Ocama Ponsiano, Cooney Matthew M, Wilson Tony, Probert Christopher S
Mbarara University Teaching Hospital, Mbarara, Uganda and the Uganda Cancer Institute, Kampala, Uganda.
Mbarara University Teaching Hospital, Mbarara Uganda.
Afr Health Sci. 2015 Sep;15(3):959-66. doi: 10.4314/ahs.v15i3.33.
There is a paucity of published data regarding upper gastrointestinal diseases in Ugandans with upper gastrointestinal symptoms referred for endoscopy.
To study the presenting complaints, pathology and Helicobacter pylori prevalence among patients with upper gastrointestinal symptoms in South-Western Uganda.
Patients presenting with upper gastrointestinal symptoms underwent upper endoscopy and a urease test for Helicobacter Pylori, all suspicious lesions were biopsied for histopathology review as appropriate.
The most common presenting complaints were epigastric pain (51.6%), dysphagia (13.6%) and odynophagia (7.1%). The most common endoscopy finding was gastritis (40.2%), followed by normal examination (15.2%), oesophageal cancer (13.6%), gastric ulcer (7.6%) and gastric cancer (7.1%). Patients older than 40 years (n=110) had significant findings including gastritis (50.9%), oesophageal cancer (22.7%) and gastric cancer (11.8%). However in younger patients, with the age range of 18-40 years (n=74), most examinations were normal (92.9%). Of the 176 patients able to undergo Helicobacter pylori testing 75.6% were positive. Helicobacter pylori infection was associated with statistically significant increase in gastritis, oesophageal cancer, gastric ulcer, gastric cancer, and duodenal ulcers (p-values< 0.05).
Gastritis, ulcerative disease, and upper gastrointestinal malignancies are common in South-Western Ugandans and are associated with a high prevalence of Helicobacter pylori.
关于因上消化道症状转诊接受内镜检查的乌干达人上消化道疾病的已发表数据较少。
研究乌干达西南部有上消化道症状患者的主诉、病理及幽门螺杆菌感染率。
有上消化道症状的患者接受上消化道内镜检查及幽门螺杆菌尿素酶试验，所有可疑病变均进行活检以进行适当的组织病理学检查。
最常见的主诉是上腹部疼痛（51.6%）、吞咽困难（13.6%）和吞咽痛（7.1%）。最常见的内镜检查发现是胃炎（40.2%），其次是检查正常（15.2%）、食管癌（13.6%）、胃溃疡（7.6%）和胃癌（7.1%）。40岁以上的患者（n = 110）有显著发现，包括胃炎（50.9%）、食管癌（22.7%）和胃癌（11.8%）。然而，在年龄范围为18 - 40岁的年轻患者中（n = 74），大多数检查结果正常（92.9%）。在176例能够进行幽门螺杆菌检测的患者中，75.6%呈阳性。幽门螺杆菌感染与胃炎、食管癌、胃溃疡、胃癌和十二指肠溃疡的统计学显著增加相关（p值<0.05）。
胃炎、溃疡性疾病和上消化道恶性肿瘤在乌干达西南部很常见，并且与幽门螺杆菌的高感染率相关。
