iACVP-MR: Accurate Identification of Anti-coronavirus Peptide based on Multiple Features Information and Recurrent Neural Network.

BACKGROUND

Over the years, viruses have caused human illness and threatened human health. Therefore, it is pressing to develop anti-coronavirus infection drugs with clear function, low cost, and high safety. Anti-coronavirus peptide (ACVP) is a key therapeutic agent against coronavirus. Traditional methods for finding ACVP need a great deal of money and man power. Hence, it is a significant task to establish intelligent computational tools to able rapid, efficient and accurate identification of ACVP.

METHODS

In this paper, we construct an excellent model named iACVP-MR to identify ACVP based on multiple features and recurrent neural networks. Multiple features are extracted by using reduced amino acid component and dipeptide component, compositions of k-spaced amino acid pairs, BLOSUM62 encoder according to the N5C5 sequence, as well as second-order moving average approach based on 16 physicochemical properties. Then, two recurrent neural networks named long-short term memory (LSTM) and bidirectional gated recurrent unit (BiGRU) combined attention mechanism are used for feature fusion and classification, respectively.

RESULTS

The accuracies of ENNAVIA-C and ENNAVIA-D datasets under the 10-fold cross-validation are 99.15% and 98.92%, respectively, and other evaluation indexes have also obtained satisfactory results. The experimental results show that our model is superior to other existing models.

CONCLUSION

The iACVP-MR model can be viewed as a powerful and intelligent tool for the accurate identification of ACVP. The datasets and source codes for iACVP-MR are freely downloaded at https://github.com/yunyunliang88/iACVP-MR.