Amendolara Alfred, Magoffin Wyatt D, Naik Aparna U, Sant David, Kriak John, Green Breniman, Bills Kyle
Federated Department of Biology, New Jersey Institute of Technology, Newark, USA.
Department of Biomedical Sciences, Noorda College of Osteopathic Medicine, Provo, USA.
Cureus. 2024 Feb 26;16(2):e54987. doi: 10.7759/cureus.54987. eCollection 2024 Feb.
Migraine is a common neurological disorder that significantly impacts patients around the world. In the United States, one in six individuals suffers from a migraine disorder. Despite its high prevalence, the etiology of migraine is not well understood. Multiple factors likely contribute to the development of both acute and chronic migraine, making the consensus as to the cause and treatment difficult. Presented here are three case studies involving adult males suffering from chronic migraine. Each subject provided a medical history and underwent physical, psychological, and neurological examinations. In addition, relevant bloodwork and cervical spine X-rays were obtained. Physical examination, laboratory studies, imaging, and psychological metrics were unremarkable with the notable exception of the three-hour oral glucose tolerance tests. All three patients displayed hypoglycemia at three hours. Furthermore, their symptoms markedly improved with the initiation of a ketogenic diet. These data are suggestive of a potential link between postprandial hypoglycemia and chronic migraine. Despite the small sample size, we feel that this report presents possible evidence for a connection between postprandial hypoglycemia and chronic migraine. Furthermore, properly controlled studies of larger sample sizes are required, but we suggest that clinicians consider screening patients for this easily overlooked metabolic disturbance, especially in the absence of other options.
偏头痛是一种常见的神经系统疾病，对全球患者都有显著影响。在美国，六分之一的人患有偏头痛疾病。尽管其患病率很高，但偏头痛的病因尚未完全明确。多种因素可能导致急性和慢性偏头痛的发生，这使得关于病因和治疗的共识难以达成。这里展示了三个涉及成年男性慢性偏头痛的病例研究。每个受试者都提供了病史，并接受了身体、心理和神经学检查。此外，还进行了相关的血液检查和颈椎X光检查。身体检查、实验室研究、影像学检查和心理指标均无异常，但三小时口服葡萄糖耐量试验是个显著例外。所有三名患者在三小时时均出现低血糖。此外，他们的症状在开始生酮饮食后明显改善。这些数据表明餐后低血糖与慢性偏头痛之间可能存在联系。尽管样本量较小，但我们认为本报告为餐后低血糖与慢性偏头痛之间的联系提供了可能的证据。此外，需要进行样本量更大的适当对照研究，但我们建议临床医生考虑对患者进行这种容易被忽视的代谢紊乱筛查，尤其是在没有其他选择的情况下。
