血小板糖蛋白IIIa多态性调节非糖尿病患者心肌梗死风险

Platelet Glycoprotein IIIa Polymorphism Modulates the Risk of Myocardial Infarction in Non-Diabetics.

作者信息

Mohamed Ahmed Mohanad Altayeb, Ali Elshazali Widaa, Alimairi Gamal Mahmoud

机构信息

Department of Haematology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan.

Department of Medical Laboratory Sciences, College of Applied Medical Sciences, University of Bisha, Bisha, Saudi Arabia.

出版信息

J Clin Med Res. 2024 Mar;16(2-3):75-80. doi: 10.14740/jocmr5094. Epub 2024 Mar 16.

DOI:10.14740/jocmr5094

PMID:38550545

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10970036/

Abstract

BACKGROUND

Genetic polymorphisms of platelet glycoprotein IIIa ( gene) have been investigated intensively in several thrombotic diseases, but their role in cardiovascular diseases remains controversial. This study aimed to investigate the association between platelet glycoprotein IIIa polymorphism and susceptibility to myocardial infarction in non-diabetics.

METHODS

A total of 200 participants were recruited for the study, 100 non-diabetic patients with myocardial infarction and 100 apparently healthy volunteers as a control group. polymorphism was analyzed by polymerase chain reaction-restriction fragment length polymorphism.

RESULTS

The distribution of polymorphic genotypes among the study groups was significantly different (P value = 0.00). The and genotypes were more frequent in the patients with myocardial infarction while the genotype was more prevalent in the control group. There was a statistically significant association between the genotype and reduced risk of both ST-segment elevation myocardial infarction (odds ratio (OR) = 0.19; 95% confidence interval (CI): 0.09 - 0.34, P value = 0.00) and non-ST-segment elevation myocardial infarction (OR = 0.21; 95% CI: 0.09 - 0.45, P value = 0.00). The genotype was found to be associated with an increased risk of both types of myocardial infarction (OR = 6.0; 95% CI: 2.61 - 13.8, P value = 0.00 for ST-segment elevation myocardial infarction and OR = 6.65; 95% CI: 2.69 - 16.45, P value = 0.00 for non- ST-segment elevation myocardial infarction. In the patients carrying the genotype, the risk of ST-segment elevation myocardial infarction was increased to about 14 folds in the presence of family history (OR: 13.57, 95% CI: 1.42 - 130.03, P value = 0.02), and the risk of non-ST-segment elevation myocardial infarction increased to about 18 folds in the smokers carrying the genotype (OR: 17.63, 95% CI: 0.96 - 324.70, P value = 0.05).

CONCLUSIONS

The genotype is associated with a reduced risk of ST-segment elevation and non-ST-segment elevation myocardial infarction, while is associated with an increased risk of both types of myocardial infarction.

摘要

背景

血小板糖蛋白IIIa（基因）的基因多态性已在多种血栓性疾病中得到深入研究，但其在心血管疾病中的作用仍存在争议。本研究旨在探讨血小板糖蛋白IIIa多态性与非糖尿病患者心肌梗死易感性之间的关联。

方法

共招募200名参与者进行研究，100名非糖尿病心肌梗死患者和100名明显健康的志愿者作为对照组。采用聚合酶链反应-限制性片段长度多态性分析多态性。

结果

研究组间多态性基因型的分布有显著差异（P值=0.00）。心肌梗死患者中基因型和基因型更为常见，而基因型在对照组中更为普遍。基因型与ST段抬高型心肌梗死风险降低（比值比（OR）=0.19；95%置信区间（CI）：0.09 - 0.34，P值=0.00）和非ST段抬高型心肌梗死风险降低（OR = 0.21；95% CI：0.09 - 0.45，P值=0.00）均存在统计学显著关联。发现基因型与两种类型的心肌梗死风险增加有关（ST段抬高型心肌梗死的OR = 6.0；95% CI：2.61 - 13.8，P值=0.00；非ST段抬高型心肌梗死的OR = 6.65；95% CI：2.69 - 16.45，P值=0.00）。在携带基因型的患者中，有家族史时ST段抬高型心肌梗死的风险增加至约14倍（OR：13.57，95% CI：1.42 - 130.03，P值=0.02），在携带基因型的吸烟者中，非ST段抬高型心肌梗死的风险增加至约18倍（OR：17.63，95% CI：0.96 - 324.70，P值=0.05）。