Kimura Taichi, Shimamura Shunsuke, Sakaya Hiroshi, Hayashi Tetsuya, Umemoto Azusa, Sakai Kosei, Yamasaki Masahiro, Hasegawa Tetsuya, Shimada Terumasa
Laboratory of Small Animal Clinical Medicine, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Izumisano, Osaka, Japan.
R&D Division, Global New Business Development Unit, Smart Appliances & Solutions BU, SHARP CORPORATION, Yao, Osaka, Japan.
Vet Med (Praha). 2024 Feb 27;69(2):42-51. doi: 10.17221/49/2023-VETMED. eCollection 2024 Feb.
Heart rate variability analyses using Poincaré plots can be useful for evaluating the autonomic nervous system function. However, the interpretation of the quantitative indicators of Poincaré plots remains controversial. Thus, few studies have verified the effectiveness of the quantitative indicators in veterinary medicine. This study aimed to verify the reliability of Poincaré plot indicators using pharmacological models in dogs. Four healthy beagles were used in this study. Each dog was treated with propranolol, atropine, and propranolol-atropine to block the sympathetic, parasympathetic, and sympathetic-parasympathetic functions, respectively. The quantitative indicators of the Poincaré plots were calculated based on data from 300 electrocardiogram beats collected before and after the administration of each drug and statistically analysed. The quantitative indicators of the Poincaré plots, such as the standard deviation perpendicular to the major axis (SD1), standard deviation along the major axis (SD2), and SD1 × SD2, significantly decreased after the drug administration in both the parasympathetic and sympathetic-parasympathetic blockade models. However, no significant differences were observed in SD1/SD2 between the groups. The Poincaré plots reflected the changes in the autonomic nervous system of dogs. In dogs, SD1, SD2, and SD1 × SD2 can detect a state in which parasympathetic nerve activity is suppressed.
使用庞加莱图进行心率变异性分析有助于评估自主神经系统功能。然而，庞加莱图定量指标的解读仍存在争议。因此，很少有研究在兽医学中验证这些定量指标的有效性。本研究旨在使用犬类药理学模型验证庞加莱图指标的可靠性。本研究使用了4只健康的比格犬。每只犬分别接受普萘洛尔、阿托品和普萘洛尔 - 阿托品治疗，以分别阻断交感神经、副交感神经和交感 - 副交感神经功能。根据每种药物给药前后收集的300次心电图搏动数据计算庞加莱图的定量指标，并进行统计分析。在副交感神经和交感 - 副交感神经阻滞模型中，给药后庞加莱图的定量指标，如垂直于主轴的标准差（SD1）、沿主轴的标准差（SD2）以及SD1×SD2均显著降低。然而，各组之间SD1/SD2未观察到显著差异。庞加莱图反映了犬自主神经系统的变化。在犬中，SD1、SD2和SD1×SD2可以检测到副交感神经活动受到抑制的状态。
