通过烯烃桥连钯（I）二聚体实现托烷多个C（sp）-H键的跨环官能化
Transannular Functionalization of Multiple C(sp)-H Bonds of Tropane via an Alkene-Bridged Palladium(I) Dimer.
作者信息
Aguilera Ellen Y, Liu En-Chih, Thullen Scott M, Sanford Melanie S
机构信息
Department of Chemistry, University of Michigan, 930 N. University Avenue, Ann Arbor, Michigan 48109, United States.
出版信息
Organometallics. 2023 Apr 24;42(8):627-631. doi: 10.1021/acs.organomet.3c00086. Epub 2023 Apr 10.
Abstract
This communication describes the Pd-catalyzed C(sp)-H functionalization of a tropane derivative to generate products with functionalization at two (β/γ) or three (β/γ/β) different sites on the alicyclic amine core. These reactions proceed via an initial dehydrogenation to generate an alkene product that can react further to form a Pd(I) alkene-bridged dimer. Functionalization of this dimer affords β/γ/β-functionalized allylic arylation and allylic acetoxylation products.
摘要
本通讯报道了钯催化的托烷衍生物的C(sp)-H官能化反应，以在脂环胺核心的两个（β/γ）或三个（β/γ/β）不同位点生成官能化产物。这些反应通过初始脱氢生成烯烃产物进行，该烯烃产物可进一步反应形成钯（I）烯烃桥联二聚体。该二聚体的官能化提供了β/γ/β-官能化的烯丙基芳基化和烯丙基乙酰氧基化产物。
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